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CBX8 Antibody (MA5-49285) in IHC (P)
Immunohistochemistry analysis of CBX8 in paraffin-embedded section of human gallbladder adenocarcinoma tissue. Heat mediated antigen retrieval was performed in EDTA buffer (pH 8.0, epitope retrieval solution). The tissue section was blocked with 10% goat serum. Samples were incubated with CBX8 Monoclonal antibody (Product # MA5-49285) using a dilution of 2 μg/mL overnight at 4°C. Biotinylated goat anti-mous... View More
Product Details
MA5-49285
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
8G7
Immunogen
E.coli-derived human Cbx8 recombinant protein (Position: M1-R389).
Conjugate
Form
Lyophilized
Concentration
500 µg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 4mg trehalose
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_3074943
Product Specific Information
Adding 0.2 mL of distilled water will yield a concentration of 500 µg/mL.
Positive Control - WB: human Hela whole cell, human A549 whole cell, human Raji whole cell. IHC: human gallbladder adenocarcinoma tissue. Flow: HL-60 cell.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Target Information
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: chromobox homolog 8 (Pc class homolog, Drosophila); Chromobox protein homolog 8; HPC3; Pc class 3 homolog; Pc3; polycomb 3; Polycomb 3 homolog; Rectachrome 1
Gene Aliases: CBX8; PC3; RC1
UniProt ID: (Human) Q9HC52
Entrez Gene ID: (Human) 57332
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
positive regulation of cell proliferation
histone ubiquitination
protein sumoylation
positive regulation of collagen biosynthetic process
positive regulation of DNA repair
regulation of catalytic activity
cellular response to hydrogen peroxide
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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