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Product Details
PA5-109485
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human CCBL1 (NP_001116144.1).
Conjugate
Form
Liquid
Concentration
0.69 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2854896
Product Specific Information
Immunogen sequence: MAKQLQARRL DGIDYNPWVE FVKLASEHDV VNLGQGFPDF PPPDFAVEAF QHAVSGDFML NQYTKTFVII IEPFFDCYEP MTMMAGGRPV FVSLKPGPIQ NGELGSSSNW QLDPMELAGK FTSRTKALVL NTPNNPLGKV FSREELELVA SLCQQHDVVC ITDEVYQWMV YDGHQHISIA SLPGMWERTL TIGSAGKTFS ATGWKVGWVL GPDHIMKHLR TVHQNSVFHC PTQSQAAVAE SFEREQLLFR QPSSYFVQFP QAMQRCRDHM
Target Information
Kynurenine aminotransferases KAT I, KAT II, and KAT III belong to the class-I pyridoxal-phosphate-dependent aminotransferase family. KAT I is a cytoplasmic protein involved in glutamine catabolism. KAT I functions in the catalysis of the transamination of L-kinurenine to form kynurenic acid, a neuroprotective and anticonvulsant metabolite of tryptophan. Kynurenic acid is involved in synaptic transmission and has been implicated in a number of neurological disorders including schizophrenia and Huntington's disease. KAT I also functions in the metabolism of cysteine conjugates in some halogenated alkenes and alkanes to form reactive metabolites. KAT I has three isoforms. Isoform 1is the full length protein, isoform 2 lacks amino acids 68-117 and isoform 3 lacks amino acids 251-422. Based on sequence similarity, KAT I is thought to function as a homodimer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: beta-lysase, kidney; cysteine conjugate beta lyase 1; cysteine conjugate-beta lyase 1; cysteine conjugate-beta lyase, cytoplasmic; cysteine conjugate-beta lyase; cytoplasmic (glutamine transaminase K, kyneurenine aminotransferase); Cysteine-S-conjugate beta-lyase; cytoplasmic (glutamine transaminase K, kyneurenine aminotransferase); Glutamine transaminase K; Glutamine--phenylpyruvate transaminase; glutamine-phenylpyruvate aminotransferase; GTK; KATI; kyneurenine aminotransferase; Kynurenine aminotransferase 1; Kynurenine aminotransferase I; kynurenine aminotransferase/glutamine transaminase K; Kynurenine--oxoglutarate transaminase 1; kynurenine--oxoglutarate transaminase 1, mitochondrial; Kynurenine--oxoglutarate transaminase I
Gene Aliases: 2010009K05Rik; AI182306; CCBL1; GTK; Kat; KAT1; KATI; KYAT1
UniProt ID: (Rat) Q08415, (Mouse) Q8BTY1, (Human) Q16773
Entrez Gene ID: (Rat) 311844, (Mouse) 70266, (Human) 883
kynurenine-oxoglutarate transaminase activity
lyase activity
pyridoxal phosphate binding
protein homodimerization activity
L-phenylalanine:pyruvate aminotransferase activity
glutamine-phenylpyruvate transaminase activity
cysteine-S-conjugate beta-lyase activity
L-glutamine:pyruvate aminotransferase activity
catalytic activity
transaminase activity
transferase activity
protein binding
transaminase
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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