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产品信息
PA5-34407
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
An 18 amino acid synthetic peptide near the amino terminus of human CCDC22
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.02% sodium azide
保存条件
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2551759
产品详细信息
A suggested positive control is 293 cell lysate.
PA5-34407 can be used with blocking peptide PEP-1449.
靶标信息
CCDC22 is a recently identified coiled-coil domain-containing protein that has been shown to bind copines, which are calcium-dependent, membrane-binding proteins that may function in calcium signaling. In rat, CCDC22 has been observed to localize in multiple regions of the brain, including the prefrontal and somatosensory cortex, dentate gyrus and thalamus, and in the ipsilateral motor neurons of the spinal cord after sciatic nerve transection suggesting that it may play a role in neuronal injury response. The human CCDC22 gene has been identified as a novel candidate gene for syndromic X-linked intellectual disability (XLID).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ccdc22 {ECO:0000250|UniProtKB:O60826}; Coiled-coil domain-containing protein 22; coiled-coil domain-containing protein 22 {ECO:0000250|UniProtKB:O60826}
基因别名: AI481216; CCDC22; CXorf37; DXImx40e; JM1; Ppp1r3f; RGD1560910; RTSC2; Sfc22
UniProt ID: (Human) O60826, (Mouse) Q9JIG7, (Rat) P86182
Entrez Gene ID: (Human) 28952, (Mouse) 54638, (Rat) 317381
cellular copper ion homeostasis
Golgi to plasma membrane transport
cytoplasmic sequestering of NF-kappaB
protein transport
positive regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
transport
