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产品信息
PA5-18384
产品规格
种属反应
Human,
Mouse
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide sequence (FDGDSDSDSQSRVRNQ) corresponding to the internal amino acids of CCKBR (aa 251-266).
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Ammonium sulfate precipitation
保存液
TBS, pH 7.3, with 0.5% BSA
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_10977181
产品详细信息
This antibody is predicted to react with bovine and mouse based on sequence homology.
This antibody is tested in Peptide ELISA: antibody detection limit dilution 32,000.
靶标信息
CCKBR is a G-protein coupled receptor for gastrin and cholecystokinin (CCK), regulatory peptides of the brain and gastrointestinal tract. This protein is a type B gastrin receptor, which has a high affinity for both sulfated and nonsulfated CCK analogs and is found principally in the central nervous system and the gastrointestinal tract. A misspliced transcript variant including an intron has been observed in cells from colorectal and pancreatic tumors. CCKBR has been reported in brain, colon, pancreas, stomach, thyroid, and various cancers.
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生物信息学
蛋白别名: CCK-B receptor; CCK-BR; CCK2 receptor; CCK2-R; CCKB; Cckb receptor; CCKB-R; Cholecystokinin-2 receptor; Cholecystokinin-B; gastrin receptor; Gastrin/cholecystokinin type B receptor; HGNC:1571
基因别名: CCK-B; CCK-BR; CCK2-R; CCK2R; CCKBR; CCKR-2; CCKRB; GASR
UniProt ID: (Human) P32239, (Mouse) P56481
Entrez Gene ID: (Human) 887, (Mouse) 12426
gastric acid secretion
cell surface receptor signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
digestion
sensory perception
feeding behavior
cell proliferation
positive regulation of cell proliferation
cholecystokinin signaling pathway
regulation of phosphatidylinositol 3-kinase activity
digestive tract development
gland development
