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CCKBR (extracellular) Antibody (ACR-042-200UL) in IHC (P)
Expression of Cholecystokinin B receptor in rat stomach - Immunohistochemical staining of paraffin embedded rat stomach sections using Anti-CCKBR (extracellular) Antibody (#ACR-042), (1:100). Cholecystokinin B receptor (brown) is expressed in both parietal cells (black arrows) and in chief cells (red arrows) of the gastric mucosa. Hematoxilin is used as the counterstain.
Product Details
ACR-042-200UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CETPRIRGTGTRELE, corresponding to amino acid residues 39-53 of mouse Gastrin/cholecystokinin type B receptor, Extracellular, N-terminus
Conjugate
Form
Lyophilized
Concentration
0.8 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 1% BSA
Contains
0.05% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C, protected from the light, for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 X g 5 min).
Target Information
CCKBR is a G-protein coupled receptor for gastrin and cholecystokinin (CCK), regulatory peptides of the brain and gastrointestinal tract. This protein is a type B gastrin receptor, which has a high affinity for both sulfated and nonsulfated CCK analogs and is found principally in the central nervous system and the gastrointestinal tract. A misspliced transcript variant including an intron has been observed in cells from colorectal and pancreatic tumors. CCKBR has been reported in brain, colon, pancreas, stomach, thyroid, and various cancers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CCK(B) receptor; CCK-B receptor; CCK-BR; CCK2 receptor; CCK2-R; CCKB; Cckb receptor; CCKB-R; Cholecystokinin-2 receptor; Cholecystokinin-B; gastrin receptor; Gastrin/cholecystokinin type B receptor; HGNC:1571
Gene Aliases: CCK-B; CCK-BR; CCK2-R; CCK2R; CCKBR; CCKR-2; CCKRB; Cholrec; GASR
UniProt ID: (Human) P32239, (Rat) P30553, (Mouse) P56481
Entrez Gene ID: (Human) 887, (Rat) 25706, (Mouse) 12426
gastric acid secretion
cell surface receptor signaling pathway
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
digestion
sensory perception
feeding behavior
cell proliferation
positive regulation of cell proliferation
cholecystokinin signaling pathway
regulation of phosphatidylinositol 3-kinase activity
digestive tract development
gland development
histamine secretion
behavioral defense response
apoptotic process
G-protein coupled receptor signaling pathway
positive regulation of synaptic transmission, GABAergic
response to insulin
estrous cycle
positive regulation of synaptic transmission
regulation of sensory perception of pain
positive regulation of synaptic transmission, glutamatergic
ERK1 and ERK2 cascade
positive regulation of somatostatin secretion
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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