Invitrogen

CCL21 Monoclonal Antibody (54111)

产品信息

MA5-23751

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1 µg/mL

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酶联免疫吸附实验 (ELISA)

0.1-0.4 µg/mL (Detection), 2-8 µg/mL (Capture)

产品规格

种属反应

Human

已发表种属

Human

宿主/亚型

Mouse / IgG1

分类

Monoclonal

类型

Antibody

克隆号

54111

抗原

E. coli-derived recombinant human CCL21/6Ckine Ser24-Pro134

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Lyophilized

浓度

0.5 mg/mL

纯化类型

Protein A/G

保存液

PBS with 5% trehalose

内含物

No Preservative

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2610503

产品详细信息

In Western blots, shows 100% cross-reactivity with recombinant human (rh) CCL24. Under reducing conditions, this antibody shows approximately 10-50% cross-reactivity with rhCCL2, 8, 13, 28, and rmCCL2. This antibody does not cross-react with rhCCL1, 3, 4, 5, 7, 9, 11, 14a, 15, 17, 18, 19, 20, 22, 23, 25, rmCCL1, 3, 4, 6, 7, 9, 11, 12, 19, 20, 21, 22, 24, 25, 28, or rrCCL20.

Reconstitute at 0.5 mg/mL in sterile PBS.

靶标信息

This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. Similar to other chemokines the protein encoded by this gene inhibits hemopoiesis and stimulates chemotaxis. This protein is chemotactic in vitro for thymocytes and activated T cells, but not for B cells, macrophages, or neutrophils. The cytokine encoded by this gene may also play a role in mediating homing of lymphocytes to secondary lymphoid organs. It is a high affinity functional ligand for chemokine receptor 7 (CCR7) that is expressed on T and B lymphocytes and a known receptor for another member of the cytokine family (small inducible cytokine A19).

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Target organ expression and biomarker characterization of chemokine CCL21 in systemic sclerosis associated pulmonary arterial hypertension.

Frontiers in immunology

Didriksen H,Molberg Ø,Mehta A,Jordan S,Palchevskiy V,Fretheim H,Gude E,Ueland T,Brunborg C,Garen T,Midtvedt Ø,Andreassen AK,Lund-Johansen F,Distler O,Belperio J,Hoffmann-Vold AM

MA5-23751 was used in ELISA, Western Blot to demonstrate expression of CCL21 in epithelial lung tissue from SSc patients with PAH, and indicate that CCL21 in SSc circulates as a truncated protein.

Tue Oct 11 00:00:00 UTC 2022

生物信息学

蛋白别名: 6 Ckine; 6Ckine; beta chemokine exodus-2; Beta-chemokine exodus-2; C-C motif chemokine 21; chemokine (C-C motif) ligand 21; Efficient Chemoattractant for Lymphocytes; secondary lymphoid tissue chemokine; Secondary lymphoid-tissue chemokine; SLC; small inducible cytokine subfamily A (Cys-Cys), member 21; Small-inducible cytokine A21

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基因别名: 6Ckine; CCL21; CKb9; ECL; SCYA21; SLC; TCA4; UNQ784/PRO1600

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UniProt ID: (Human) O00585

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Entrez Gene ID: (Human) 6366

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功能

chemokine activity CCR7 chemokine receptor binding chemokine receptor binding CCR chemokine receptor binding cytokine intercellular signal molecule

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