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Product Details
H00000905-M03
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
1H3
Immunogen
CCNT2 (NP_490595, 264 a.a. approximately 370 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Product may be used with Western Blot (Cell lysate).
Immunogen sequence: RKPKVDGQVS ETPLLGSSLV QNSILVDSVT GVPTNPSFQK PSTSAFPAPV PLNSGNISVQ DSHTSDNLSM LATGMPSTSY GLSSHQEWPQ HQDSARTEQL YSQKQET
Target Information
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin and its kinase partner CDK9 were found to be subunits of the transcription elongation factor p-TEFb. The p-TEFb complex containing this cyclin was reported to interact with, and act as a negative regulator of human immunodeficiency virus type 1 (HIV-1) Tat protein. A pseudogene of this gene is found on chromosome 1. Alternate splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cyclin T2a; cyclin T2b; Cyclin-T2; CycT2; SDS-stable vimentin-bound DNA fragment HEF42VIM22; subunit of positive elongation transcription factor b
Gene Aliases: CCNT2; CYCT2
UniProt ID: (Human) O60583
Entrez Gene ID: (Human) 905
regulation of cyclin-dependent protein serine/threonine kinase activity
transcription from RNA polymerase II promoter
transcription elongation from RNA polymerase II promoter
protein phosphorylation
cell cycle
early viral transcription
late viral transcription
snRNA transcription from RNA polymerase II promoter
positive regulation of cyclin-dependent protein serine/threonine kinase activity
positive regulation of transcription from RNA polymerase II promoter
cell division
positive regulation of phosphorylation of RNA polymerase II C-terminal domain
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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