Invitrogen

CD100 Monoclonal Antibody (547412)

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CD100 Antibody (MA5-24248) in Flow

Flow cytometry of CD100 in Mouse splenocytes. Samples were incubated in CD100 monoclonal antibody (Product # MA5-24248) or isotype control antibody followed by Phycoerythrin-conjugated Anti-Rat IgG F(ab)2 Secondary Antibody.

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产品信息

MA5-24248

应用

建议稀释比

已发表文章

流式细胞分析 (Flow)

2.5 µg per million cells

产品规格

种属反应

Mouse

宿主/亚型

Rat / IgG2b

分类

Monoclonal

类型

Antibody

克隆号

547412

抗原

Mouse myeloma cell line NS0-derived recombinant mouse Semaphorin 4D/CD100 Phe24-Thr657

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Lyophilized

浓度

0.5 mg/mL

纯化类型

Protein A/G

保存液

PBS with 5% trehalose

内含物

No Preservative

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

AB_2610476

产品详细信息

In direct ELISAs, no cross-reactivity with recombinant human Semaphorin 3A, 3B, 3C, 3D, 3E, 3F, 4A, 4B, 4C, 4D, 4G, 5A, 5B, 6A, 6B, 6C, 6D, or 7A is observed.

Reconstitute in sterile PBS to a final concentration of 0.5 mg/mL.

靶标信息

Semaphorins are neuronal chemorepellants that direct pioneering neurons during nervous system development. CD100 (also known as semaphorin 4d), a 150 kDa homodimer, is a novel semaphorin that induces B cells to aggregate and improves their viability in vitro. CD100 modifies CD40-CD40L B cell signaling by augmenting B cell aggregation and survival and down regulating CD23 expression. CD72 is a lymphocyte receptor for the class IV semaphorin CD100, which is involved in regulating B cell signaling. CD100 is expressed on resting and PHA stimulated T cells. The protein is weakly expressed on NK cells, EBV transformed B cells, monocytes and tumor/peripheral blood T cell lines, and at higher density on activated T cells and B cells.

仅用于科研。不用于诊断过程。未经明确授权不得转售。