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CD100 (SEMA4D) Antibody (MA5-43159) in Flow
Flow Cytometry analysis of CD100 (SEMA4D) in untransfected HEK293T cells (green line) and transfected Human SEMA4D HEK293T stable cells (red line) using CD100 (SEMA4D) Monoclonal Antibody (Product # MA5-43159) (2 µg/1x10^6cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody.
产品信息
MA5-43159
产品规格
种属反应
Human
宿主/亚型
Human
/ IgG4
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
21E8
抗原
Recombinant Human SEMA4D protein
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.03% ProClin 300
保存条件
-20°C or -80°C if preferred
运输条件
Wet ice
RRID
AB_2912295
产品详细信息
Antibody tested in Indirect ELISA
靶标信息
Semaphorins are neuronal chemorepellants that direct pioneering neurons during nervous system development. CD100 (also known as semaphorin 4d), a 150 kDa homodimer, is a novel semaphorin that induces B cells to aggregate and improves their viability in vitro. CD100 modifies CD40-CD40L B cell signaling by augmenting B cell aggregation and survival and down regulating CD23 expression. CD72 is a lymphocyte receptor for the class IV semaphorin CD100, which is involved in regulating B cell signaling. CD100 is expressed on resting and PHA stimulated T cells. The protein is weakly expressed on NK cells, EBV transformed B cells, monocytes and tumor/peripheral blood T cell lines, and at higher density on activated T cells and B cells.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: A8; BB18; CD100; GR3; sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D; sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, 4D; Semaphorin-4D
基因别名: C9orf164; CD100; coll-4; M-sema-G; SEMA4D; SEMAJ
UniProt ID: (Human) Q92854
Entrez Gene ID: (Human) 10507
negative regulation of transcription from RNA polymerase II promoter
neural crest cell migration
positive regulation of protein phosphorylation
immune response
cell adhesion
negative regulation of cell adhesion
regulation of cell shape
negative regulation of alkaline phosphatase activity
positive regulation of phosphatidylinositol 3-kinase signaling
positive regulation of cell migration
regulation of cell projection organization
negative regulation of apoptotic process
positive regulation of GTPase activity
ossification involved in bone maturation
negative regulation of osteoblast differentiation
positive regulation of collateral sprouting
regulation of dendrite morphogenesis
negative regulation of axon extension involved in axon guidance
positive regulation of peptidyl-tyrosine phosphorylation
negative regulation of peptidyl-tyrosine phosphorylation
negative chemotaxis
leukocyte aggregation
semaphorin-plexin signaling pathway
semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis
