Invitrogen

CD105 Polyclonal Antibody

查看其他84个CD105 (Endoglin)抗体

抗体检测数据 (3)

CD105 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

CD105 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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CD105 Antibody (PA5-27205) in IHC (P)

Immunohistochemical analysis of paraffin-embedded SCC15 xenograft, using CD105 (Product # PA5-27205) antibody at 1:100 dilution. Antigen Retrieval: EDTA based buffer, pH 8.0, 15 min.

CD105 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

CD105 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

CD105 Antibody in Western Blot (WB)

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CD105 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemical analysis of paraffin-embedded SCC15 xenograft, using CD105 (Product # PA5-27205) antibody at 1:100 dilution. Antigen Retrieval: EDTA based buffer, pH 8.0, 15 min.

CD105 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — CD105 Polyclonal Antibody detects CD105 protein at cell membrane and cytoplasm by immunohistochemical analysis. Sample: Paraffin-embedded mouse white adipocyte. CD105 stained by CD105 Polyclonal Antibody (Product # PA5-27205) diluted at 1:500. Antigen Retrieval: Citrate buffer, pH 6.0, 15 min.

CD105 Antibody in Western Blot (WB) — Western Blot using CD105 Polyclonal Antibody (Product # PA5-27205). Whole cell extract (30 µg) was separated by 7.5% SDS-PAGE, and the membrane was blotted with CD105 Polyclonal Antibody (Product # PA5-27205) diluted at 1:1,000.

产品信息

PA5-27205

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:3,000

-

免疫组化（石蜡） (IHC (P))

1:100-1:1,000

-

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant fragment corresponding to a region within amino acids 309 and 606 of Human CD105

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

0.1M tris glycine, pH 7, with 10% glycerol

内含物

0.01% thimerosal

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

AB_2544681

产品详细信息

Recommended positive controls: 293T, A431, H1299, HeLaS3, HepG2, Molt-4, Raji.

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

靶标信息

CD105 or Endoglin is a Type I transmembrane protein, which is highly expressed on human vascular endothelial cells. It exists on an O- and N-glycosylated homodimer. Up regulation of endoglin expression has been demonstrated in tumor vasculature and proliferating cells, suggesting that it is a proliferation associated endothelial marker. CD105 binds to TGF beta 1 and 3 with high affinity but not to TGF beta 2.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: CD105; CD105 antigen; Endoglin; ORW

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基因别名: END; ENG; HHT1; ORW1

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UniProt ID: (Human) P17813

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Entrez Gene ID: (Human) 2022

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transmembrane signaling receptor activity transforming growth factor beta receptor, cytoplasmic mediator activity type II transforming growth factor beta receptor binding protein binding galactose binding glycosaminoglycan binding type I transforming growth factor beta receptor binding BMP binding protein homodimerization activity activin binding transforming growth factor beta binding transmembrane signal receptor

chronological cell aging patterning of blood vessels vasculogenesis positive regulation of protein phosphorylation heart looping sprouting angiogenesis endocardial cushion morphogenesis cardiac ventricle morphogenesis cardiac atrium morphogenesis ventricular trabecula myocardium morphogenesis cell migration involved in endocardial cushion formation regulation of transcription, DNA-templated cell adhesion negative regulation of gene expression positive regulation of pathway-restricted SMAD protein phosphorylation regulation of transforming growth factor beta receptor signaling pathway central nervous system vasculogenesis negative regulation of cell migration BMP signaling pathway positive regulation of BMP signaling pathway negative regulation of protein autophosphorylation dorsal aorta morphogenesis positive regulation of angiogenesis positive regulation of transcription from RNA polymerase II promoter smooth muscle tissue development artery morphogenesis venous blood vessel morphogenesis endocardial cushion to mesenchymal transition positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation