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Invitrogen
CD119 (IFN gamma Receptor 1) Monoclonal Antibody (GR-20), Functional Grade, eBioscience™
产品信息
16-1193-85
应用
建议稀释比
已发表文章
产品规格
种属反应
Mouse
宿主/亚型
Rat
/ IgG2a, kappa
分类
Monoclonal
类型
Antibody
克隆号
GR-20
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.2
内含物
no preservative
保存条件
4° C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2573079
产品详细信息
Description: The monoclonal antibody GR-20 recognizes mouse CD119 also known as IFN gamma receptor 1. CD119 heterodimerizes with IFN gamma receptor 2 (AF-1) forming the Class II cytokine receptor. The ligand IFN gamma binds IFN gamma receptor 1 subunit but signal transduction transpires via the IFN gamma receptor 2 subunit. The receptor is involved in host defense and expression is broad including B cells, NK cells, macrophages and dendritic cells as well as other non-hematopoietic cell types. The GR-20 antibody has been reported to block IFN gamma binding to CD119.
Applications Reported: This GR-20 antibody has been reported for use in flow cytometric analysis and functional assays (blocking cytokine binding to the receptor).
Storage and handling: Use in a sterile environment.
Filtration: 0.2 µm post-manufacturing filtered.
Purity: Greater than 90%, as determined by SDS-PAGE.
Endotoxin Level: Less than 0.001 ng/µg antibody, as determined by LAL assay.
Aggregation: Less than 10%, as determined by HPLC.
靶标信息
This gene (IFNGR1) encodes the ligand-binding chain (alpha) of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. A genetic variation in IFNGR1 is associated with susceptibility to Helicobacter pylori infection. In addition, defects in IFNGR1 are a cause of mendelian susceptibility to mycobacterial disease, also known as familial disseminated atypical mycobacterial infection.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CD119; IFN-gamma receptor 1; IFN-gamma-R-alpha; IFN-gamma-R1; INF-g receptor; Interferon gamma receptor 1; Interferon gamma receptor alpha-chain; interferon-gamma receptor 1
基因别名: CD119; Ifgr; IFN-gammaR; Ifngr; Ifngr1; Nktar
UniProt ID: (Mouse) P15261
Entrez Gene ID: (Mouse) 15979
