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Invitrogen
CD124 Recombinant Rabbit Monoclonal Antibody (Astra-1), Alexa Fluor™ 647, eBioscience™
图: 1 / 2
CD124 Antibody (51-1241-82) in Flow
BALB/c mouse splenocytes were stained with CD45R (B220) Monoclonal Antibody, eFluor 450 (Product # 48-0452-82) and 0.03 µg of Recombinant Rabbit IgG Monoclonal Isotype Control, Alexa Fluor 647 (Product # 51-4616-82) (left) or 0.03 µg of CD124 Recombinant Rabbit Monoclonal Antibody, Alexa Fluor 647 (right). Viable cells were used for analysis, as determined by Fixable Viability Dye eFluor 780 (Product # 65-0865-18).
产品信息
51-1241-82
产品规格
种属反应
Mouse
宿主/亚型
Rabbit
/ IgG
Expression System
Expi293
分类
Recombinant Monoclonal
类型
Antibody
克隆号
Astra-1
抗原
Protein corresponding to mouse CD124 (aa26-aa233)
偶联物
激发/发射光谱
650/671 nm
查看光谱
形式
Liquid
浓度
0.2 mg/mL
纯化类型
Protein A
保存液
proprietary buffer/PBS, pH 7.2
内含物
0.09% sodium azide
保存条件
4° C, store in dark, DO NOT FREEZE!
运输条件
Wet ice
RRID
AB_2848400
产品详细信息
Description: This Astra-1 recombinant rabbit monoclonal antibody reacts with mouse CD124, which is also known as the IL4 receptor alpha (IL4RA) chain.
Applications Tested: This Astra-1 antibody has been tested by flow cytometric analysis of mouse splenocytes. This may be used at less than or equal to 0.06 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.
Excitation: 633-647 nm; Emission: 668 nm; Laser: Red Laser
Filtration: 0.2 µm post-manufacturing filtered.
靶标信息
IL4 Receptor alpha (IL4RA) is the alpha chain of the interleukin 4 receptor which binds to both interleukin 4 and interleukin 13 to regulate IgE production, chemokine and mucus production at sites of allergic inflammmation. The IL4 response is involved in promoting Th2 differentiation. The secreted extracellular domain of IL4R alpha, called sIL4R alpha, can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. It has no signaling abilities. Allelic variations in the IL4RA gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CD124; il-4 receptor; IL-4 receptor alpha chain; IL-4 receptor subunit alpha; IL-4R subunit alpha; IL-4R-alpha; IL-4RA; Interleukin-4 receptor subunit alpha
基因别名: CD124; Il4r; Il4ra
UniProt ID: (Mouse) P16382
Entrez Gene ID: (Mouse) 16190
immune system process
production of molecular mediator involved in inflammatory response
positive regulation of immunoglobulin production
immunoglobulin mediated immune response
regulation of cell proliferation
defense response to protozoan
positive regulation of macrophage activation
positive regulation of mast cell degranulation
negative regulation of T-helper 1 cell differentiation
positive regulation of T-helper 2 cell differentiation
positive regulation of chemokine secretion
positive regulation of myoblast fusion
