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CD134 (OX40) Antibody (13-1347-42) in Flow
Normal human peripheral blood cells were unstimulated (left) or stimulated for 72 hours with PHA-L Solution (Product # 00-4977-03). Cells were then stained with CD134 (OX40) Monoclonal Antibody, Biotin, followed by Streptavidin, PE (Product # 12-4317-87) and CD3 Monoclonal Antibody, APC (Product # 17-0037-42). Viable cells in the lymphocyte gate were used for analysis, as determined by 7-AAD (Product # 00-6993-50).
产品信息
13-1347-42
应用
建议稀释比
已发表文章
产品规格
已发表种属
Not Applicable
宿主/亚型
Mouse
/ IgG1, kappa
分类
Monoclonal
类型
Antibody
克隆号
ACT35 (ACT-35)
偶联物
形式
Liquid
浓度
5 µL/Test
保存条件
4° C, do not freeze
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2815059
产品详细信息
Description: The ACT35 monoclonal antibody reacts with human CD134, also known as OX-40. A member of the TNF receptor superfamily, CD134/OX-40 is a 50 kDa type I membrane glycoprotein expressed by activated T lymphocytes. The interaction of CD134 with OX-40L has been implicated in T cell-dependent humoral response, regulation of primary T cell expansion, survival of T cells, size of the memory T cell pool and regulation of tolerance in the CD4^+ T cell compartment.
Applications Reported: This ACT35 (ACT-35) antibody has been reported for use in flow cytometric analysis.
Applications Tested: This ACT35 (ACT-35) antibody has been pre-diluted and tested by flow cytometric analysis of stimulated normal human peripheral blood cells. This may be used at 5 µL (0.25 µg) per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test.
靶标信息
OX40 is a protein receptor found on the surface of T cells, a type of white blood cell that plays a crucial role in the immune system. When activated, OX40 promotes the proliferation and survival of T cells, leading to a stronger immune response against cancer cells and infectious agents. OX40 agonists, which are drugs that activate OX40, have shown promising results in preclinical and clinical studies as a potential immunotherapy for cancer. They can enhance the efficacy of other cancer treatments such as chemotherapy and checkpoint inhibitors, and may also have applications in autoimmune diseases and allergies.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
