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CD154 (CD40 Ligand) Antibody (MA1-10108) in Flow
Separation of CD154 positive cells (red-filled) from CD154 negative cells (black-dashed) in flow cytometry analysis (surface staining) of PMA, ionomycin and LPS stimulated mouse splenocytes stained using anti-mouse CD154 (MR-1) purified Monoclonal antibody (Product # MA1-10108). Low endotoxin, concentration in sample 3 µg/mL, GAArH APC.
产品信息
MA1-10108
应用
建议稀释比
已发表文章
产品规格
种属反应
Mouse
已发表种属
Mouse
宿主/亚型
Armenian hamster
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
MR-1
抗原
Activated mouse Th1 clone D1.6
偶联物
形式
Liquid
浓度
1.0 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
4° C, do not freeze
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_11153361
产品详细信息
This antibody detects an extracellular epitope on murine CD154 / CD40L (CD40-ligand), a 39 kDa cell surface type II glycoprotein expressed predominantly on activated CD4+ lymphocytes.
Endotoxin level is less than 0.01 EU/µg of the protein, as determined by the LAL test.
Functional Application: Blocking.
靶标信息
CD40 Ligand (CD40-L), or CD154, is a membrane glycoprotein and differentiation antigen expressed on the surface of T cells. The CD40 Ligand stimulates B cell proliferation and secretion of all immunoglobulin isotypes in the presence of cytokines. CD40 Ligand has been shown to induce cytokine production and tumoricidal activity in peripheral blood monocytes. It also co-stimulates proliferation of activated T cells and this is accompanied by the production of IFN-gamma, TNF-alpha, and IL-2.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: CD154; CD40 ligand; CD40 ligand, membrane form; CD40 ligand, soluble form; CD40-L; H-CD-40-L; M-CD-40-L; RP23-153G22.3; sCD40L; T-cell antigen Gp39; TNF-related activation protein; TRAP; Tumor necrosis factor ligand superfamily member 5
基因别名: CD154; CD40-L; Cd40l; Cd40lg; gp39; HIGM1; IGM; IMD3; Ly-62; Ly62; T-BAM; Tnfsf5; TRAP
UniProt ID: (Mouse) P27548
Entrez Gene ID: (Mouse) 21947
positive regulation of immune response to tumor cell
inflammatory response
immune response
signal transduction
platelet activation
B cell differentiation
positive regulation of B cell proliferation
positive regulation of interferon-gamma production
positive regulation of interleukin-10 production
positive regulation of interleukin-12 production
B cell proliferation
negative regulation of apoptotic process
isotype switching
positive regulation of MHC class II biosynthetic process
immunoglobulin secretion
regulation of immunoglobulin secretion
dendritic cell differentiation
positive regulation of endothelial cell apoptotic process
