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CD16 Antibody (MA5-40921) in Flow
Flow cytometric analysis of Mouse CD16 expression on mouse splenocytes. BABL/c splenocytes were stained with CD16 Recombinant Rabbit Monoclonal Antibody (002), PerCP (Product # MA5-40921) and FITC-conjugated anti-Mouse CD3. The dot plots were derived from events with the forward and side light-scatter characteristics of intact cells.
产品信息
MA5-40921
产品规格
种属反应
Mouse
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
002
抗原
Recombinant Mouse CD16/FCGR3 protein
偶联物
激发/发射光谱
482/675 nm
查看光谱
形式
Liquid
浓度
0.1 mg/mL
纯化类型
Protein A
保存液
PBS with 0.5% BSA
内含物
0.09% sodium azide
保存条件
4° C, store in dark, DO NOT FREEZE!
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2898682
产品详细信息
May be stored for twelve months without detectable loss of activity. Protect from prolonged exposure to light and do not freeze. Sodium azide is toxic to cells and should be disposed of properly so flush with large volumes of water during disposal.
靶标信息
CD16 encodes a receptor that recognizes the Fc portion of immunoglobulin G and is involved in the clearance of immune complexes from the circulation, as well as other functions such as cellular mediated cytotoxicity and enhancement of virus infections. This gene, FCGR3A, shares a high degree of similarity with another nearby gene, FCGR3B, located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, while FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been associated with immunodeficiency 20 and have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. Diseases associated with FCGR3A include Immunodeficiency 20 and Herpes Zoster.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CD16-2; CD16a; CD32; CD32 receptor 2; CDw32; Fc fragment of IgG, low affinity IIIa, receptor for (CD16); Fc fragment of IgG, low affinity III, receptor for (CD16); Fc gamma receptor III; Fc gammaRIV; Fc receptor-like 3; Fc-gamma RII-b; Fc-gamma RII-c; fc-gamma RIII; Fc-gamma-RIIb; Fc-gamma-RIIc; Fcg receptor III; FCG2; FcgammaRIII; FcgammaRIV; FCGR2; FCGR2A; FCGR2B; FCGR2C; FcRII-b; FcRII-c; fcRIII; igG Fc receptor III; IgG Fc receptor III-A; low affinity immunoglobulin gamma Fc region receptor III; Low affinity immunoglobulin gamma Fc region receptor III-A; RP11-5K23.1
基因别名: 4833442P21Rik; CD16; CD16-2; FcgammaRIV; Fcgr3a; Fcgr4; FcgRIV; Fcrl3
UniProt ID: (Mouse) A0A0B4J1G0
Entrez Gene ID: (Mouse) 14131, (Mouse) 246256
antibody-dependent cellular cytotoxicity
positive regulation of type IIa hypersensitivity
positive regulation of type III hypersensitivity
positive regulation of type I hypersensitivity
serotonin secretion
phagocytosis, recognition
phagocytosis, engulfment
cell surface receptor signaling pathway
neutrophil chemotaxis
Fc-gamma receptor signaling pathway
positive regulation of tumor necrosis factor biosynthetic process
antigen processing and presentation of exogenous peptide antigen via MHC class I
mast cell activation
positive regulation of phagocytosis
regulation of immune response
NK T cell proliferation
regulation of sensory perception of pain
cellular response to lipopolysaccharide
