Invitrogen

CD1a Monoclonal Antibody (O10)

CD1a Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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CD1a Antibody (MA5-12526) in IHC (P)

Formalin-fixed, paraffin-embedded human tonsil stained with CD1a antibody using peroxidase-conjugate and AEC chromogen. Note membrane staining of interdigitating cells of stratified squamous epithelium of tonsil.

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产品信息

MA5-12526

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:100-1:1,000

免疫组化 (IHC)

查看8篇已发表文章 8篇已发表文章

免疫组化（石蜡） (IHC (P))

1:50-1:100

查看3篇已发表文章 3篇已发表文章

免疫细胞化学 (ICC/IF)

查看2篇已发表文章 2篇已发表文章

流式细胞分析 (Flow)

2 µg/test

产品规格

种属反应

Human, Mouse

已发表种属

Human, Rhesus monkey

宿主/亚型

Mouse / IgG1, kappa

分类

Monoclonal

类型

Antibody

克隆号

O10

抗原

Human thymus cells

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.2 mg/mL

纯化类型

Protein A/G

保存液

PBS, pH 7.4, with 0.05% BSA

内含物

0.05% sodium azide

保存条件

4° C

运输条件

Ambient (domestic); Wet ice (international)

AB_10943672

产品详细信息

This antibody detects CD1a in mouse and human samples in FACS, WB and IHC (P) applications.

靶标信息

CD1a is a non-polymorphic MHC Class 1 related cell surface glycoprotein, expressed in association with Beta 2 microglobulin. CD1a is expressed by cortical thymocytes, Langerhan's cells and by interdigitating cells. CD1a is also expressed by some malignancies of T cell lineage and in histiocytosis X. CD1a is expressed on cortical thymocytes, epidermal Langerhans cells, dendritic cells, on certain T-cell leukemias, and in various other tissues. CD1a is structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. CD1a localizes to the plasma membrane and recycles vesicles of the early endocytic system. At least five CD1 genes (CD1a, b, c, d, and e) are identified. Alternatively spliced transcript variants of CD1a have been observed, but their biological validity have not been determined.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Immune myopathy with large histiocyte-related myofiber necrosis.

Neurology

Pestronk A,Sinha N,Alhumayyd Z,Ly C,Schmidt R,Bucelli R

MA5-12526 was used in Immunohistochemistry to describe the features of a new, pathologically distinctive, acquired myopathy with an unusual pattern of scattered necrotic muscle fibers that are neighbored, surrounded, or invaded, by large, often multinucleated, histiocytic cells.

Tue Apr 09 00:00:00 UTC 2019

Optimization of Single- and Dual-Color Immunofluorescence Protocols for Formalin-Fixed, Paraffin-Embedded Archival Tissues.

The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society

Kajimura J,Ito R,Manley NR,Hale LP

MA512526 was used in immunohistochemistry - paraffin section to study thymus tissues derived from autopsies of individuals exposed to atomic bomb radiation in Hiroshima

Mon Feb 01 00:00:00 UTC 2016

Fibroblastic reticular cell tumor of the breast: A case report and review of the literature.

Experimental and therapeutic medicine

Li H,Shen P,Liang Y,Zhang F

MA512526 was used in immunohistochemistry - paraffin section to characterize and present the first case of fibroblastic reticular cell tumor of the breast

Mon Feb 01 00:00:00 UTC 2016

Periluminal Distribution of HIV-Binding Target Cells and Gp340 in the Oral, Cervical and Sigmoid/Rectal Mucosae: A Mapping Study.

PloS one

Patyka M,Malamud D,Weissman D,Abrams WR,Kurago Z

MA5-12526 was used in immunohistochemistry - paraffin section to determine the periluminal distribution of CD4+ HIV target cells

Tue Apr 26 00:00:00 UTC 2016

An intraosseous sclerosing odontogenic tumor predominantly composed of epithelial cells: relation to (so-called) sclerosing odontogenic carcinoma and epithelial-rich central odontogenic fibroma.

Oral surgery, oral medicine, oral pathology and oral radiology

Tan SH,Yeo JF,Kheem Pang BN,Petersson F

MA5-12526 was used in immunohistochemistry to report on a case of an intraosseous sclerosing odontogenic tumor in a 31 year-old woman

Wed Oct 01 00:00:00 UTC 2014

Role of Langerhans cells, Ki-67 protein and apoptosis in acquired cholesteatoma: prospective clinical study.

The Journal of laryngology and otology

Akdogan V,Yilmaz I,Canpolat T,Ozluoglu LN

MA5-12526 was used in immunohistochemistry to study the role of Langerhans cells in the pathogenesis of acquired cholesteatoma

Fri Mar 01 00:00:00 UTC 2013

Immunogenicity of DNA vaccines encoding simian immunodeficiency virus antigen targeted to dendritic cells in rhesus macaques.

PloS one

Tenbusch M,Ignatius R,Nchinda G,Trumpfheller C,Salazar AM,Töpfer K,Sauermann U,Wagner R,Hannaman D,Tenner-Racz K,Racz P,Stahl-Hennig C,Uberla K

MA5-12526 was used in immunocytochemistry to study the effect on immunogenicity of targeting DNA vaccines encoding SIV antigen to dendritic cells in a non-human primate model

Thu Dec 13 00:00:00 UTC 2012

CXCL17 and ICAM2 are associated with a potential anti-tumor immune response in early intraepithelial stages of human pancreatic carcinogenesis.

Gastroenterology

Hiraoka N,Yamazaki-Itoh R,Ino Y,Mizuguchi Y,Yamada T,Hirohashi S,Kanai Y

MA5-12526 was used in immunohistochemistry to study the association of CXCL17 and ICAM2 with a potential anti-tumor immune response in early stage pancreatic tumorigenesis

Sat Jan 01 00:00:00 UTC 2011

Biomolecular network reconstruction identifies T-cell homing factors associated with survival in colorectal cancer.

Gastroenterology

Mlecnik B,Tosolini M,Charoentong P,Kirilovsky A,Bindea G,Berger A,Camus M,Gillard M,Bruneval P,Fridman WH,Pagès F,Trajanoski Z,Galon J

MA5-12526 was used in immunohistochemistry to use biomolecular network reconstruction to investigate the immune responses in colorectal cancer patients

Thu Apr 01 00:00:00 UTC 2010

Coordination of intratumoral immune reaction and human colorectal cancer recurrence.

Cancer research

Camus M,Tosolini M,Mlecnik B,Pagès F,Kirilovsky A,Berger A,Costes A,Bindea G,Charoentong P,Bruneval P,Trajanoski Z,Fridman WH,Galon J

MA5-12526 was used in immunohistochemistry to study the correlation of intratumoral immune markers and human colorectal cancer escape

Sun Mar 15 00:00:00 UTC 2009

Altered expression of the receptor-ligand pair CXCR5/CXCL13 in B cells during chronic HIV-1 infection.

Blood

Cagigi A,Mowafi F,Phuong Dang LV,Tenner-Racz K,Atlas A,Grutzmeier S,Racz P,Chiodi F,Nilsson A

MA5-12526 was used in immunohistochemistry to study the expression of the receptor-ligand pair CXCR5/CXCL13 in B cells during chronic HIV-1 infection

Mon Dec 01 00:00:00 UTC 2008

Epithelioid smooth muscle tumors of the uterus do not express CD1a: a potential immunohistochemical adjunct in their distinction from uterine perivascular epithelioid cell tumors.

Annals of diagnostic pathology

Fadare O,Liang SX

MA5-12526 was used in immunohistochemistry to investigate the level of CD1a in uterine epithelioid smooth muscle tumors

Mon Dec 01 00:00:00 UTC 2008

Tumor-derived TGFbeta-1 induces dendritic cell apoptosis in the sentinel lymph node.

Journal of immunology (Baltimore, Md. : 1950)

Ito M,Minamiya Y,Kawai H,Saito S,Saito H,Nakagawa T,Imai K,Hirokawa M,Ogawa J

MA5-12526 was used in immunocytochemistry to study the role of tumor-derived TGFbeta-1 in dendritic cell apoptosis in the sentinel lymph node

Mon May 01 00:00:00 UTC 2006

生物信息学

蛋白别名: CD1a; CD1A antigen, a polypeptide; cluster of differentiation 1 A; cortical thymocyte antigen CD1A; differentiation antigen CD1-alpha-3; epidermal dendritic cell marker CD1a; hTa1 thymocyte antigen; T-cell surface antigen T6/Leu-6; T-cell surface glycoprotein CD1a

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基因别名: CD1; CD1A; FCB6; HTA1; R4; T6

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UniProt ID: (Human) P06126

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Entrez Gene ID: (Human) 909

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功能

protein binding beta-2-microglobulin binding endogenous lipid antigen binding exogenous lipid antigen binding lipopeptide binding major histocompatibility complex protein

参与通路

adaptive immune response immune response antigen processing and presentation, exogenous lipid antigen via MHC class Ib regulation of immune response