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产品信息
PA5-95920
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 20-190 of human CD1D (NP_0017571)
偶联物
形式
Liquid
浓度
1.16 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2807722
产品详细信息
Immunogen sequence: EVPQRLFPLR CLQISSFANS SWTRTDGLAW LGELQTHSWS NDSDTVRSLK PWSQGTFSDQ QWETLQHIFR VYRSSFTRDV KEFAKMLRLS YPLELQVSAG CEVHPGNASN NFFHVAFQGK DILSFQGTSW EPTQEAPLWV NLAIQVLNQD KWTRETVQWL LNGTCPQFVS G; Positive Samples: K-562, Jurkat, Mouse liver; Cellular Location: Cell membrane, Endosome membrane, Lysosome membrane, Single-pass type I membrane protein
靶标信息
CD1d is a heavy chain associated with Beta 2 microglobulin on cortical thymocytes. Beta 2 microglobulin independent expression of CD1d has also been demonstrated on human intestinal epithelial cells. CD1d is the sole group 2 member of the CD1 family of major histocompatibility (MHC) like glycoproteins. The CD1d gene encodes a divergent member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by the CD1d gene localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail. Diseases associated with CD1D include Mycobacterium Malmoense and Autoimmune Disease.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Antigen-presenting glycoprotein CD1d; Antigen-presenting glycoprotein CD1d1; CD1d; CD1D antigen, d polypeptide; CD1d.1; differentiation antigen CD1-alpha-3; HMC class I antigen-like glycoprotein CD1D; R3G1; T-cell surface glycoprotein CD1d; T-cell surface glycoprotein CD1d1; thymocyte antigen CD1D
基因别名: AI747460; CD1.1; CD1A; CD1D; Cd1d1; Ly-38; R3; R3G1
UniProt ID: (Human) P15813, (Mouse) P11609
Entrez Gene ID: (Human) 912, (Mouse) 12479
viral process
detection of bacterium
heterotypic cell-cell adhesion
positive regulation of T cell proliferation
T cell selection
innate immune response
positive regulation of innate immune response
antigen processing and presentation, endogenous lipid antigen via MHC class Ib
antigen processing and presentation, exogenous lipid antigen via MHC class Ib
regulation of immune response
positive regulation of T cell mediated cytotoxicity
immune system process
immune response
antigen processing and presentation
positive regulation of macrophage activation
positive thymic T cell selection
positive regulation of interferon-gamma biosynthetic process
positive regulation of interleukin-2 biosynthetic process
positive regulation of interleukin-4 biosynthetic process
positive regulation of NK T cell activation
positive regulation of NK T cell differentiation
