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CD204 Antibody (MA1-81060) in WB
Proceedings of the National Academy of Sciences of the United States of America 2013 -
Fig. 6. Correlation between uptake of SNAs and expression level of CAV-1 and SR-A. ( A ) To probe the general importance of CAV-1 and SR-A, we selected three other cell lines besides C166 for additional investigation. They include HaCaT (immortal human keratinocyte), 3T3 (mouse fibroblast), and A549 (human lung epithelial adenocarcinoma). All are responsive to the treatment of FCD and Poly I, as evidenced b... View More
产品信息
MA1-81060
产品规格
种属反应
Fish,
Mouse,
Pig
已发表种属
Human,
Mouse
宿主/亚型
Rat
/ IgG2b
分类
Monoclonal
类型
Antibody
克隆号
2F8
抗原
RAW264 cell line.
偶联物
激发/发射光谱
498/517 nm
查看光谱
形式
Liquid
浓度
0.1 mg/mL
纯化类型
Protein G
保存液
PBS with 1% BSA
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Store in the dark.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2251086
产品详细信息
For FACS analysis, use 10 µL of the suggested working dilution to label 1x10^6 cells in 100 µL.
Rat anti Mouse CD204 antibody, clone 2F8 recognizes the murine scavenger receptor class A (SRA), type I and II, also known as CD204.
靶标信息
CD204 gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. Diseases associated with MSR1 include Barrett Esophagus and Prostate Cancer.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
How to use the Panel Builder
Watch the video to learn how to use the Invitrogen Flow Cytometry Panel Builder to build your next flow cytometry panel in 5 easy steps.
生物信息学
蛋白别名: CD204; Macrophage acetylated LDL receptor I and II; Macrophage scavenger receptor types I and II; Scavenger receptor type A; SR-A; SR-AI/II
基因别名: MRS-A; MSR; MSR-A; Msr1; Scara1; Scvr; SR-AI; SR-AII
UniProt ID: (Mouse) P30204
Entrez Gene ID: (Pig) 100511665, (Mouse) 20288
