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CD205 Antibody (PA5-87607) in WB
Western blot analysis of CD205 in various lysates. Samples were incubated with CD205 Polyclonal antibody (Product # PA5-87607) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 180s.
产品信息
PA5-87607
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 216-501 of human LY75 (NP_0023402)
偶联物
形式
Liquid
浓度
1.15 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2804286
产品详细信息
Positive Samples: Mouse lung; Cellular Location: Membrane, Single-pass type I membrane protein
Immunogen sequence: CEDNWEKNEQ FGSCYQFNTQ TALSWKEAYV SCQNQGADLL SINSAAELTY LKEKEGIAKI FWIGLNQLYS ARGWEWSDHK PLNFLNWDPD RPSAPTIGGS SCARMDAESG LWQSFSCEAQ LPYVCRKPLN NTVELTDVWT YSDTRCDAGW LPNNGFCYLL VNESNSWDKA HAKCKAFSSD LISIHSLADV EVVVTKLHNE DIKEEVWIGL KNINIPTLFQ WSDGTEVTLT YWDENEPNVP YNKTPNCVSY LGELGQWKVQ SCEEKLKYVC KRKGEKLNDA SSDKMC
靶标信息
CD205 (LY25, Lymphocyte Antigen 75) is an integral membrane glycoprotein involved in antigen uptake, trafficking and presentation that improves the induction of antigen-specific T cell immunity. CD205 is highly expressed by CD8+ dendritic cells (DCs) and also expressed at different levels by bone marrow Gr1+ cells, Langerhans cells, (BMDC) bone marrow derived DCs and thymic epithelial cells. CD205 acts as an endocytic receptor that directs captured antigens to the extracellular space towards a specialized antigen processing region. Further, CD205 also prompts the reduced proliferation of B lymphocytes. Diseases associated with CD205 dysfunction include pneumonic plague and lipid pneumonia.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: C-type lectin domain family 13 member B; CA-IX; CD205; DCL-1 fusion; DEC-205; gp200; gp200-MR6; Ly-75; Lymphocyte antigen 75; membrane antigen MN; P54/58N; pMW1; RP23-10L17.4
基因别名: CD205; CLEC13B; DEC-205; DEC205; GP200-MR6; LY-75; LY75
UniProt ID: (Human) O60449, (Mouse) Q60767
Entrez Gene ID: (Human) 4065, (Mouse) 17076
