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产品信息
16-2101-85
应用
建议稀释比
已发表文章
产品规格
种属反应
Mouse
已发表种属
Mouse
宿主/亚型
Rat
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
1B1.3a
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.2
内含物
no preservative
保存条件
4° C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2573082
产品详细信息
Description: The 1B1.3A monoclonal antibody reacts with mouse CD210, which is also known as the IL-10 receptor. CD210 is a member of the interferon receptor-like family that is expressed on a variety of hematopoietic cells, including thymocytes, T cells, B cells, NK cells, monocytes, and macrophages. Binding of IL-10 to its receptor initiates JAK/STAT signaling that leads to B cell proliferation and inhibition of macrophage activation.
The 1B1.3A antibody has been reported to have neutralizing activity.
Applications Reported: The 1B1.3A antibody has been reported for use in functional assays.
Storage and handling: Use in a sterile environment.
Filtration: 0.2 µm post-manufacturing filtered.
Purity: Greater than 90%, as determined by SDS-PAGE.
Endotoxin Level: Less than 0.001 ng/µg antibody, as determined by LAL assay.
Aggregation: Less than 10%, as determined by HPLC.
靶标信息
The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: CD210; CDw210a; CDW210B; CRF2-4; CRFB4; D21S58; D21S66; I10R; I10R1; il-10 receptor; il-10 receptor antagonist; IL-10 receptor subunit alpha; IL-10R alpha; IL-10R subunit 1; IL-10R subunit alpha; IL-10R1; IL-10R2; IL-10RA; Interleukin-10 receptor subunit 1; Interleukin-10 receptor subunit alpha
基因别名: AW553859; CDw210; CDw210a; Il10r; Il10ra; mIL-10R
UniProt ID: (Mouse) Q61727
Entrez Gene ID: (Mouse) 16154
