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CD223 Chimeric Antibody (MA5-48212) in ICC/IF
Immunocytochemistry/Immunofluorescence analysis of LAG-3 (CD223) in mouse splenocytes using CD223 Chimeric Monoclonal Antibody (Product # MA5-48212). Paraformaldehyde-fixed cells were immobilized on cover slips and stained with CD223 Chimeric Monoclonal Antibody at 10 µg/mL followed by Alexa Fluor 488 secondary antibody (2 µg/mL), showing membrane staining in subset of cells. The nuclear stain is DAPI (blue... View More
产品信息
MA5-48212
应用
建议稀释比
已发表文章
产品规格
种属反应
Mouse
宿主/亚型
Rabbit
/ IgG, kappa
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
C9B7W
抗原
This antibody was raised by immunising Lewis rats with a murine LAG-3:Ig fusion protein.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS
内含物
0.02% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_3074655
产品详细信息
Specificity: This antibody is specific for an epitope in the D2 domain of murine LAG-3.
靶标信息
LAG-3 is a 70-kDa surface glycoprotein belonging to the Ig superfamily with homology to CD4. LAG-3 binds to MHC class II with higher affinity than CD4 and is thought to be involved in the negative regulation of T cell activation and homeostatic proliferation. Surface expression of LAG-3 has been reported on activated T cells (including regulatory T cells) and NK cells. CD8+ T cells usually express LAG-3 at significantly higher levels than CD4+ T cells. Coexpression of LAG-3 and CD49b has been proposed to identify human and mouse Type 1 regulatory T cells (Tr1 cells).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Activation-induced cytidine deaminase-linked autoimmunity protein; Aida; CD223; LAG-3; Lymphocyte activation gene 3 protein; sLAG 3; sLAG3; soluble LAG 3lymphocyte activating 3; soluble LAG3
基因别名: CD223; LAG-3; Lag3; Ly66
UniProt ID: (Mouse) Q61790
Entrez Gene ID: (Mouse) 16768
