Invitrogen

CD23 Monoclonal Antibody (B3B4), APC

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CD23 Antibody (MCD2305) in Flow

The Journal of experimental medicine 2015 - Figure 2. B cell-specific deletion of ERK5 reduces B2 cell numbers. (A) Purified splenic FM B cells from mb1-cre + erk5 fl/fl mice and mb1-cre + erk5 wt/wt control mice were analyzed for ERK5 expression by immunoblotting. (B-F) Flow cytometric analysis of B cell populations in mb1-cre + erk5 wt/wt and mb1-cre + erk5 fl/fl mice from the indicated organs, as shown in Fig. S2 . (B) Absolute numbe... View More

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产品信息

MCD2305

应用

建议稀释比

已发表文章

流式细胞分析 (Flow)

Assay-dependent

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其他PubMed (Misc)

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产品规格

种属反应

Mouse

已发表种属

Mouse

宿主/亚型

Rat / IgG2a

分类

Monoclonal

类型

Antibody

克隆号

B3B4

抗原

Mouse CD23.

偶联物

APC APC APC

激发/发射光谱

651/660 nm 查看光谱

形式

Liquid

浓度

0.2 mg/mL

纯化类型

purified

保存液

PBS, pH 7.2, with sucrose, 4mg/mL BSA

内含物

0.1% sodium azide

保存条件

4° C

运输条件

Ambient (domestic); Wet ice (international)

AB_10375870

靶标信息

CD23 is a 45 kDa glycoprotein which is present on a subpopulation of freshly isolated peripheral blood and tonsil B cells and strongly expressed on EBV-transformed B lymphoblasts. The CD23 molecule is identical to the low affinity IgE receptor found on B cells. Expression of CD23 has been detected in neoplastic cells from cases of B cell chronic lymphocyctic leukaemia and some cases of centroblastic/centrocytic lymphoma. CD23 is present on a subpopulation of freshly isolated peripheral blood and tonsil B cells and strongly expressed on EBV-transformed B lymphoblasts. Functionally, CD23 is involved in B cell growth and differentiation, and IgE production. Further, CD23 has a soluble form that is a potent mitogenic factor. Diseases associated with CD23 dysfunction include chronic conjunctivitis and chronic lymphocytic leukemia.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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Product References

Chitinase-3-like 1 regulates T_H2 cells, T_FH cells and IgE responses to helminth infection.

Frontiers in immunology

Curtiss ML,Rosenberg AF,Scharer CD,Mousseau B,Benavides NAB,Bradley JE,León B,Steele C,Randall TD,Lund FE

MCD2305 was used in Flow cytometry/Cell sorting to suggest that Chi3l1 modulates IgE responses, which are known to be highly dependent on IL-4-producing TFH cells.

Sat Aug 19 00:00:00 UTC 2023

The Transcription Factor NFATc1 Supports the Rejection of Heterotopic Heart Allografts.

Frontiers in immunology

Baur J,Otto C,Steger U,Klein-Hessling S,Muhammad K,Pusch T,Murti K,Wismer R,Germer CT,Klein I,Müller N,Serfling E,Avots A

MCD2305 was used in Flow cytometry/Cell sorting to show that the activity of nuclear factors of activated T cells-c1 supports the acute rejection of heterotopic heart allografts.

Wed Nov 20 00:00:00 UTC 2019

TLR4 signals in B lymphocytes are transduced via the B cell antigen receptor and SYK.

The Journal of experimental medicine

Schweighoffer E,Nys J,Vanes L,Smithers N,Tybulewicz VLJ

MCD2305 was used in flow cytometry to show that TLR4 signals through the BCR leading to activation of SYK, ERK, and AKT as well as through MYD88 leading to activation of NFkappaB

Mon May 01 00:00:00 UTC 2017

BAFF activation of the ERK5 MAP kinase pathway regulates B cell survival.

The Journal of experimental medicine

Jacque E,Schweighoffer E,Tybulewicz VL,Ley SC

MCD2305 was used in flow cytometry to study the effect of ERK1/2 and ERK5 activation on BAFF-induced B cell survival

Mon Jun 01 00:00:00 UTC 2015

IKK-induced NF-κB1 p105 proteolysis is critical for B cell antibody responses to T cell-dependent antigen.

The Journal of experimental medicine

Jacque E,Schweighoffer E,Visekruna A,Papoutsopoulou S,Janzen J,Zillwood R,Tarlinton DM,Tybulewicz VL,Ley SC

MCD2305 was used in flow cytometry to study IκB kinase-induced proteolysis of NF-κB1 p105 in B cells using Nfkb1(SSAA/SSAA) mice.

Mon Sep 22 00:00:00 UTC 2014

IL-4 regulates Bim expression and promotes B cell maturation in synergy with BAFF conferring resistance to cell death at negative selection checkpoints.

Journal of immunology (Baltimore, Md. : 1950)

Granato A,Hayashi EA,Baptista BJ,Bellio M,Nobrega A

MCD2305 was used in Flow cytometry/Cell sorting to analyze the effect of IL-4 on B cell maturation, and its influence on BCR-mediated negative selection.

Sun Jun 15 00:00:00 UTC 2014

IKKα-mediated signaling circuitry regulates early B lymphopoiesis during hematopoiesis.

Blood

Balkhi MY,Willette-Brown J,Zhu F,Chen Z,Liu S,Guttridge DC,Karin M,Hu Y

MCD2305 was used in Flow Cytometry to demonstrate that IKKα regulates B-lineage commitment via combined canonical and noncanonical NF-κB transcriptional activities to target Pax5 expression during hematopoiesis.

Thu Jun 07 00:00:00 UTC 2012

TLR4 promotes B cell maturation: independence and cooperation with B lymphocyte-activating factor.

Journal of immunology (Baltimore, Md. : 1950)

Hayashi EA,Granato A,Paiva LS,Bertho AL,Bellio M,Nobrega A

MCD2305 was used in flow cytometry to report the cell surface markers and functional properties of B cells matured in vitro with LPS

Sat May 01 00:00:00 UTC 2010

IkappaBalpha is required for marginal zone B cell lineage development.

European journal of immunology

Ellinghaus U,Rupec RA,Pabst O,Ignatius R,Förster R,Dörken B,Jundt F

MCD2305 was used in flow cytometry to investigate the role of nuclear factor-kappaB signaling in the development of marginal zone B cells

Fri Aug 01 00:00:00 UTC 2008

生物信息学

蛋白别名: CD23; FC epsilon RII; Fc-epsilon-RII; FceRII; Low affinity immunoglobulin epsilon Fc receptor; low-affinity IgE receptor; Lymphocyte IgE receptor

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基因别名: CD23; Fce2; Fcer2; Fcer2a; Ly-42

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UniProt ID: (Mouse) P20693

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Entrez Gene ID: (Mouse) 14128

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功能

IgE binding carbohydrate binding metal ion binding membrane traffic protein

参与通路

positive regulation of humoral immune response mediated by circulating immunoglobulin positive regulation of nitric-oxide synthase activity positive regulation of killing of cells of other organism positive regulation of nitric-oxide synthase biosynthetic process