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CD275 (B7-H2) Antibody (PA5-96572) in IHC (P)
Immunohistochemistry analysis of CD275 (B7-H2) in paraffin-embedded human skin carcinoma. Samples were incubated with CD275 (B7-H2) Polyclonal antibody (Product # PA5-96572) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
产品信息
PA5-96572
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 19-256 of human ICOSL (NP_0560741)
偶联物
形式
Liquid
浓度
1.48 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2808374
产品详细信息
Immunogen sequence: DTQEKEVRAM VGSDVELSCA CPEGSRFDLN DVYVYWQTSE SKTVVTYHIP QNSSLENVDS RYRNRALMSP AGMLRGDFSL RLFNVTPQDE QKFHCLVLSQ SLGFQEVLSV EVTLHVAANF SVPVVSAPHS PSQDELTFTC TSINGYPRPN VYWINKTDNS LLDQALQNDT VFLNMRGLYD VVSVLRIART PSVNIGCCIE NVLLQQNLTV GSQTGNDIGE RDKITENPVS TGEKNAAT; Positive Samples: HL-60, BT-474, Mouse heart, Mouse brain, Rat spleen; Cellular Location: Membrane, Single-pass type I membrane protein
靶标信息
Inducible co-stimulator ligand (ICOSL) is a specific ligand on antigen-presenting cells and cells of the peripheral tissue that binds to the inducible co-stimulator receptor (ICOS). ICOS belongs to the CD28/CD152 receptor family that regulates T-cell activation and function. ICOSL is expressed on monocytes, dendritic cells and B cells and can be induced by inflammatory stimuli in peripheral tissue. Binding to ICOSL delivers a co-stimulatory signal for T cell proliferation and cytokine secretion.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: B7 homolog 2; B7 homologue 2; B7-H2; B7-like protein Gl50; B7-related protein 1; B7RP-1; CD275; ICOS ligand; inducible T-cell co-stimulator ligand; LICOS; transmembrane protein B7-H2 ICOS ligand
基因别名: AU044799; B7-H2; B7h; B7H2; B7RP-1; B7RP1; BG071784; CD275; GI50; GL50; GL50-B; ICOS-L; ICOSL; ICOSLG; KIAA0653; LICOS; Ly115l; mKIAA0653; RGD1562791
UniProt ID: (Human) O75144, (Mouse) Q9JHJ8
Entrez Gene ID: (Human) 23308, (Mouse) 50723, (Rat) 499415
