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CD299 (DC-SIGN/L) Chimeric Antibody (MA5-47780) in ICC/IF
Immunocytochemistry/Immunofluorescence analysis of CD299 in HeLa cells using CD299 (DC-SIGN/L) Chimeric Monoclonal Antibody (Product # MA5-47780). Paraformaldehyde-fixed cells were stained with CD299 (DC-SIGN/L) Chimeric Monoclonal Antibody at 10 µg/mL for 1h followed by Alexa Fluor488 secondary antibody (1 µg/mL), showing cytoplasmic staining. The nuclear stain is DAPI (blue). Panels show from left-right, ... View More
产品信息
MA5-47780
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG, kappa
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
16E7
抗原
CD299
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS
内含物
0.02% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_3074229
产品详细信息
Specificity: Human CD299, which is an oligomeric type II transmembrane protein with a C-type lectin extracellular domain, the expression of which is restricted to immature DC, macrophages in the lung, and endothelial cells in the liver. It binds ICAM-3 and ICAM-7 to mediate the interaction of DC with T lymphocytes and endothelial cells in the initial stages of immune response and in the migratory behavior of DC. CD299 also binds the gp120 protein of HIV and the E2 envelope protein of HCV, thereby playing a role in viral infection.
靶标信息
CLEC4M is a type II integral membrane protein that is 77% identical to CD209 antigen, a HIV gp120-binding protein. This protein, like CD209, efficiently binds both intercellular adhesion molecule 3 (ICAM3) and HIV-1 gp120, and enhances HIV-1 infection of T cells.Western blots using two different antibodies against two unique regions of this protein target confirm the same apparent molecular weight in our tests.This gene encodes a type II integral membrane protein that is 77% identical to CD209 antigen, a HIV gp120-binding protein. This protein, like CD209, efficiently binds both intercellular adhesion molecule 3 (ICAM3) and HIV-1 gp120, and enhances HIV-1 infection of T cells. This gene is mapped to 19p13.3, in a cluster with the CD209 and CD23/FCER2 genes. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: C-type lectin domain family 4 member M; C-type lectin domain family 4, member M; CD209 antigen-like protein 1; CD299; CD299 antigen; DC-SIGN-related protein; DC-SIGN2; DC-SIGNR; Dendritic cell-specific ICAM-3-grabbing non-integrin 2; L-SIGN; liver/lymph node-specific ICAM-3 grabbing non-integrin; Liver/lymph node-specific ICAM-3-grabbing non-integrin; mannose binding C-type lectin DC-SIGNR; MGC129964; MGC47866
基因别名: CD209L; CD209L1; CD299; CLEC4M; DC-SIGN2; DC-SIGNR; DCSIGNR; HP10347; L-SIGN; LSIGN
UniProt ID: (Human) Q9H8F0
Entrez Gene ID: (Human) 10332
adaptive immune response
endocytosis
leukocyte cell-cell adhesion
cell-cell recognition
regulation of gene expression
modulation by virus of host morphology or physiology
virion attachment to host cell
viral genome replication
antigen processing and presentation
regulation of blood coagulation
intracellular signal transduction
innate immune response
viral entry into host cell
peptide antigen transport
intracellular transport of virus
