Invitrogen

CD34 Monoclonal Antibody (BI-3C5)

CD34 Antibody in Immunohistochemistry (IHC)

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CD34 Antibody (07-3403) in IHC

Immunohistochemcial staining of human kidney tissue using Ms ant-CD34 (clone BI-3C5) (Product # 07-3403).

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产品信息

07-3403

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:2,000

查看1篇已发表文章 1篇已发表文章

免疫组化 (IHC)

Assay-dependent

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免疫细胞化学 (ICC/IF)

查看1篇已发表文章 1篇已发表文章

流式细胞分析 (Flow)

1:25-1:50

查看2篇已发表文章 2篇已发表文章

其他PubMed (Misc)

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产品规格

种属反应

Human

已发表种属

Human

宿主/亚型

Mouse / IgG1

分类

Monoclonal

类型

Antibody

克隆号

BI-3C5

抗原

to the human CD4

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Affinity chromatography

保存液

PBS, pH 8.2

内含物

0.1% sodium azide

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

AB_2532257

靶标信息

CD34 is a highly glycosylated monomeric with a molecular weight range of 111-115 kDa surface protein that is present on many stem cell populations. CD34 is a stem cell marker although its expression on human hematopoietic stem cells is reversible. CD34 may serve as a surface receptor that undergoes receptor-mediated endocytosis and regulates adhesion, differentiation and proliferation of hematopoietic stem cells and other progenitors. CD34 expression is likely to represent a specific state of hematopoietic development that may have altered adhering properties with expanding and differentiating capabilities in both in vitro and in vivo conditions. CD34 is possibly an adhesion molecule with a putative role for mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Further, CD34 could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. CD34 is thought to have a role in presenting carbohydrate ligands to selectins. The intracellular chain of the CD34 antigen is a site of phosphorylation by activated protein kinase C suggesting a putative role in signal transduction. Diseases associated with CD34 dysfunction include dermatofibrosarcoma and neurofibroma.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Vascular histopathology and connective tissue ultrastructure in spontaneous coronary artery dissection: pathophysiological and clinical implications.

Cardiovascular research

Margaritis M,Saini F,Baranowska-Clarke AA,Parsons S,Vink A,Budgeon C,Allcock N,Wagner BE,Samani NJ,von der Thüsen J,Robertus JL,Sheppard MN,Adlam D

07-3403 was used in Immunohistochemistry to conclude that although SCAD is rarely associated with hereditary connective tissue disorders, there does not seem to be a more generalizable global connective tissue ultrastructural abnormality in most cases.

Wed Jun 22 00:00:00 UTC 2022

The presence of vessels encapsulating tumor clusters is associated with an immunosuppressive tumor microenvironment in hepatocellular carcinoma.

International journal of cancer

Zhang P,Ono A,Fujii Y,Hayes CN,Tamura Y,Miura R,Shirane Y,Nakahara H,Yamauchi M,Uchikawa S,Uchida T,Teraoka Y,Fujino H,Nakahara T,Murakami E,Miki D,Kawaoka T,Okamoto W,Makokha GN,Imamura M,Arihiro K,Kobayashi T,Ohdan H,Fujita M,Nakagawa H,Chayama K,Aikata H

07-3403 was used in Immunohistochemistry to demonstrate that VETC+ HCC is associated with suppression of tumor immune responses at the molecular level.

Thu Dec 15 00:00:00 UTC 2022

Smarcad1 mediates microbiota-induced inflammation in mouse and coordinates gene expression in the intestinal epithelium.

Genome biology

Kazakevych J,Denizot J,Liebert A,Portovedo M,Mosavie M,Jain P,Stellato C,Fraser C,Corrêa RO,Célestine M,Mattiuz R,Okkenhaug H,Miller JR,Vinolo MAR,Veldhoen M,Varga-Weisz P

Published figure using CD34 monoclonal antibody (Product # 07-3403) in Flow Cytometry

Wed Mar 11 00:00:00 UTC 2020

Human blood vessel organoids as a model of diabetic vasculopathy.

Nature

Wimmer RA,Leopoldi A,Aichinger M,Wick N,Hantusch B,Novatchkova M,Taubenschmid J,Hämmerle M,Esk C,Bagley JA,Lindenhofer D,Chen G,Boehm M,Agu CA,Yang F,Fu B,Zuber J,Knoblich JA,Kerjaschki D,Penninger JM

07-3403 was used in Immunohistochemistry to suggest that blood vessel organoids derived from human stem cells faithfully recapitulate the structure and function of human blood vessels and are a suitable model for diabetic vasculopathy.

Tue Jan 01 00:00:00 UTC 2019

Differences in the distribution of CD20, CD3, CD34 and CD45RO in nasal mucosa and polyps from patients with chronic rhinosinusitis.

Molecular medicine reports

Mitroi M,Albulescu D,Capitanescu A,Docea AO,Musat G,Mitroi G,Zlatian O,Tsatsakis A,Tzanakakis G,Spandidos DA,Calina D

07-3403 was used in Immunohistochemistry to assess the inflammatory infiltrate that characterises nasal polyps in patients with chronic rhinosinusitis and nasal polyposis.

Mon Apr 01 00:00:00 UTC 2019

Antiallodynic Effects of Cannabinoid Receptor 2 (CB₂R) Agonists on Retrovirus Infection-Induced Neuropathic Pain.

Pain research & management

Sheng WS,Chauhan P,Hu S,Prasad S,Lokensgard JR

Published figure using CD34 monoclonal antibody (Product # 07-3403) in Flow Cytometry

Mon Dec 16 00:00:00 UTC 2019

Characterization of Tunneling Nanotubes in Wharton's jelly Mesenchymal Stem Cells. An Intercellular Exchange of Components between Neighboring Cells.

Stem cell reviews and reports

Sanchez V,Villalba N,Fiore L,Luzzani C,Miriuka S,Boveris A,Gelpi RJ,Brusco A,Poderoso JJ

07-3403 was used in Immunocytochemistry to describe cells suitable for an eventual regenerative medicine.

Tue Aug 01 00:00:00 UTC 2017

Myofibrotic malformation vessels: unique angiodysplasia toward the progression of hemorrhoidal disease.

Drug design, development and therapy

Li SL,Jing FY,Ma LL,Guo LL,Na F,An SL,Ye Y,Yang JM,Bao M,Kang D,Sun XL,Deng YJ

07-3403 was used in immunohistochemistry - paraffin section to study angiodysplasia and other pathological changes associated with symptomatic hemorrhoids

Fri Jun 03 00:00:00 UTC 2016

Maternal microchimerism: increased in the insulin positive compartment of type 1 diabetes pancreas but not in infiltrating immune cells or replicating islet cells.

PloS one

Ye J,Vives-Pi M,Gillespie KM

07-3403 was used in immunohistochemistry (paraffin) to define the cellular phenotype of maternal microchimeric cells in control and type 1 diabetes pancreas.

Tue Oct 28 00:00:00 UTC 2014

Is mammary not otherwise specified-type sarcoma with CD10 expression a distinct entity? A rare case report with immunohistochemical and ultrastructural study.

Diagnostic pathology

Yang GZ,Li J,Jin H,Ding HY

07-3403 was used in immunohistochemistry to present a case of not otherwise specified-type sarcoma with CD10 expression in the left breast.

Mon Jan 28 00:00:00 UTC 2013

Mitochondrial proteomics of the retinal pigment epithelium at progressive stages of age-related macular degeneration.

Investigative ophthalmology & visual science

Nordgaard CL,Karunadharma PP,Feng X,Olsen TW,Ferrington DA

07-3403 was used in western blot to examine the subproteome of mitochondria isolated from human donor retinal pigment epithelium graded with the Minnesota Grading System

Tue Jul 01 00:00:00 UTC 2008

Recurrent intracranial hemangiopericytoma with multiple metastases.

Chinese medical journal

Cao Y,Zhang MZ,Wang JM,Zhang W,Li G,Zhao JZ

07-3403 was used in immunohistochemistry to discuss recurrent intracranial hemangiopericytoma with multiple metastases

Fri Jan 20 00:00:00 UTC 2006

Endothelial nitric oxide synthase is expressed in amacrine cells of developing human retinas.

Investigative ophthalmology & visual science

Li S,Tay D,Shu S,Bao X,Wu Y,Wang X,Yip HK

07-3403 was used in Immunohistochemistry to examine the expression and cellular distribution pattern of endothelial nitric oxide synthase in the developing human retina and compare its expression with that in rats.