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Invitrogen
CD357 (AITR/GITR) Chimeric Recombinant Rabbit Monoclonal Antibody (YGITR765)
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CD357 (AITR/GITR) Chimeric Antibody (MA5-48021) in ICC/IF
Immunocytochemistry/Immunofluorescence analysis of GITR in mouse splenocytes using CD357 (AITR/GITR) Chimeric Monoclonal Antibody (Product # MA5-48021). Paraformaldehyde-fixed cells were immobilized on cover slips and stained with CD357 (AITR/GITR) Chimeric Monoclonal Antibody at 10 µg/mL for 1h followed by Alexa Fluor488 secondary antibody (1 µg/mL), showing membrane staining in a subset of cells. The nucl... View More
产品信息
MA5-48021
产品规格
种属反应
Mouse
宿主/亚型
Rabbit
/ IgG, kappa
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
YGITR765
抗原
nB2/6TG cells transfected with mouse GITR injected into DA rats.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS
内含物
0.02% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_3074464
产品详细信息
Specificity: This antibody binds murine GITR.
靶标信息
Tumor necrosis factor receptor superfamily member 18 (TNFRSF18), also called GITR or AITR is a protein that in humans is encoded by the TNFRSF18 gene. It is mapped to 1p36.33. This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25 (+)CD4 (+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CD357; Glucocorticoid-induced TNFR-related protein; PRO364; Tumor necrosis factor receptor superfamily member 18; UNQ319
基因别名: AITR; Gitr; Tnfrsf18
UniProt ID: (Mouse) O35714
Entrez Gene ID: (Mouse) 21936
