Invitrogen

CD38 Monoclonal Antibody (HIT2)

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CD38 Antibody (MA1-19316) in Flow

Separation of human monocytes (red-filled) from CD38 negative lymphocytes (black-dashed) in flow cytometry analysis (surface staining) of peripheral whole blood stained using anti-human CD38 (HIT2) purified Monoclonal antibody (Product # MA1-19316) (concentration in sample 2 µg/mL, GAM APC).

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产品信息

MA1-19316

应用

建议稀释比

已发表文章

免疫印迹 (WB)

2 µg/mL

免疫组化 (IHC)

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免疫组化（石蜡） (IHC (P))

10 µg/mL

免疫组化（冰冻） (IHC (F))

Assay-dependent

流式细胞分析 (Flow)

1-4 µg/mL

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其他PubMed (MISC)

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产品规格

种属反应

Human

已发表种属

Human

宿主/亚型

Mouse / IgG1

分类

Monoclonal

类型

Antibody

克隆号

抗原

Fetal human thymocytes.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A

保存液

PBS, pH 7.4

内含物

15mM sodium azide

保存条件

4° C, do not freeze

运输条件

Ambient (domestic); Wet ice (international)

AB_1072231

产品详细信息

This antibody reacts with an extracellular epitope of CD38, a 45 kDa type II transmembrane glycoprotein strongly expressed mainly on plasma cells and activated T and B lymphocytes; it is an antigenic marker of lymphoid cells. Its binding is blocked by daratumumab.

A suggested positive control for this product is RAJI human cells.

Western Blot: non-reducing conditions.

靶标信息

CD38 (NAD+ glycohydrolase) is a type II transmembrane glycoprotein able to induce activation, proliferation and differentiation of mature lymphocytes and mediate apoptosis of myeloid and lymphoid progenitor cells. CD38 functions as a multi-catalytic ectoenzyme serving as ADP-ribosyl cyclase, cyclic ADP-ribose hydrolase and possibly NAD+ glycohydrolase or as a cell surface receptor. Antibodies to CD38 are useful in subtyping of lymphomas and leukemias, detection of plasma cells (i.e. identification of myelomas), and as a marker for activated B and T cells. CD38 participates in cell adhesion, signal transduction and calcium signaling. Further, CD38 is expressed at high levels in the pancreas, liver, kidney, malignant lymphoma and neuroblastoma. Diseases associated with CD38 dysfunction include chronic lymphocytic leukemia and Richter's Syndrome.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

CD38 plays an age-related role in cholinergic deregulation of airway smooth muscle contractility.

The Journal of allergy and clinical immunology

Bai Y,Guedes AGP,Krishnan R,Ai X

MA1-19316 was used in Immunohistochemistry to establish the functional connection between cholinergic stimulation and ASM contractility in different human age groups.

Sun May 01 00:00:00 UTC 2022

Targeting type I interferon-mediated activation restores immune function in chronic HIV infection.

The Journal of clinical investigation

Zhen A,Rezek V,Youn C,Lam B,Chang N,Rick J,Carrillo M,Martin H,Kasparian S,Syed P,Rice N,Brooks DG,Kitchen SG

MA1-19316 was used in flow cytometry to study the restoration of immune function in chronic HIV infection

Tue Jan 03 00:00:00 UTC 2017

Perturbed CD8⁺ T cell TIGIT/CD226/PVR axis despite early initiation of antiretroviral treatment in HIV infected individuals.

Scientific reports

Tauriainen J,Scharf L,Frederiksen J,Naji A,Ljunggren HG,Sönnerborg A,Lund O,Reyes-Terán G,Hecht FM,Deeks SG,Betts MR,Buggert M,Karlsson AC

MA119316 was used in flow cytometry to show T cell immunoglobulin and ITIM domain expression increases over time despite early initiation of antiretroviral treatment

Fri Jan 13 00:00:00 UTC 2017

Checkpoints for Autoreactive B Cells in the Peripheral Blood of Lupus Patients Assessed by Flow Cytometry.

Arthritis & rheumatology (Hoboken, N.J.)

Malkiel S,Jeganathan V,Wolfson S,Manjarrez Orduño N,Marasco E,Aranow C,Mackay M,Gregersen PK,Diamond B

MA119316 was used in flow cytometry to develop a method to detect circulating B cells that recognize nuclear antigens in patients

Thu Sep 01 00:00:00 UTC 2016

Particular activation phenotype of T cells expressing HLA-DR but not CD38 in GALT from HIV-controllers is associated with immune regulation and delayed progression to AIDS.

Immunologic research

Gonzalez SM,Taborda NA,Correa LA,Castro GA,Hernandez JC,Montoya CJ,Rugeles MT

MA119316 was used in flow cytometry to characterize the gut-associated lymphoid tissue of HIV-controllers

Wed Jun 01 00:00:00 UTC 2016

Increased Steady-State Memory B Cell Subsets Among High-Risk Participants in an HIV Vaccine Trial.

AIDS research and human retroviruses

Keefer MC,Zheng B,Rosenberg AF,Kobie JJ

MA119316 was used in flow cytometry to investigate how differences in B cell populations may contribute to HIV susceptibility

Mon Dec 18 00:00:00 UTC 2017

Humoral Dysregulation Associated with Increased Systemic Inflammation among Injection Heroin Users.

PloS one

Piepenbrink MS,Samuel M,Zheng B,Carter B,Fucile C,Bunce C,Kiebala M,Khan AA,Thakar J,Maggirwar SB,Morse D,Rosenberg AF,Haughey NJ,Valenti W,Keefer MC,Kobie JJ

MA119316 was used in flow cytometry to characterize B cells and antibody repertoires from injection drug users

Mon Jul 31 00:00:00 UTC 2017

Activated memory B cells may function as antigen-presenting cells in the joints of children with juvenile idiopathic arthritis.

Arthritis and rheumatism

Morbach H,Wiegering V,Richl P,Schwarz T,Suffa N,Eichhorn EM,Eyrich M,Girschick HJ

MA1-19316 was used in Flow cytometry/Cell sorting to investigate whether synovial B cells in juvenile idiopathic arthritis display features of antigen-presenting cells.

Tue Nov 01 00:00:00 UTC 2011

In vivo evaluation of human hematopoiesis through xenotransplantation of purified hematopoietic stem cells from umbilical cord blood.

Nature protocols

Park CY,Majeti R,Weissman IL

MA1-19316 was used in flow cytometry to develop a xenotransplantation system using human hematopoietic stem cells and mice

Wed Apr 01 00:00:00 UTC 2009

Activated memory B cell subsets correlate with disease activity in systemic lupus erythematosus: delineation by expression of CD27, IgD, and CD95.

Arthritis and rheumatism

Jacobi AM,Reiter K,Mackay M,Aranow C,Hiepe F,Radbruch A,Hansen A,Burmester GR,Diamond B,Lipsky PE,Dörner T

MA1-19316 was used in flow cytometry to identify changes in peripheral B cell subsets in patients with systemic lupus erythematosus

Sun Jun 01 00:00:00 UTC 2008

A novel human B cell subpopulation representing the initial germinal center population to express AID.

Blood

Kolar GR,Mehta D,Pelayo R,Capra JD

MA1-19316 was used in flow cytometry to characterize B cells in human tonsils

Thu Mar 15 00:00:00 UTC 2007

Molecular signature of CD34(+) hematopoietic stem and progenitor cells of patients with CML in chronic phase.

Leukemia

Diaz-Blanco E,Bruns I,Neumann F,Fischer JC,Graef T,Rosskopf M,Brors B,Pechtel S,Bork S,Koch A,Baer A,Rohr UP,Kobbe G,von Haeseler A,Gattermann N,Haas R,Kronenwett R

MA1-19316 was used in flow cytometry to characterize CD34+ cells from bone marrow of untreated patients with chronic myelogenous leukemia in chronic phase

Thu Mar 01 00:00:00 UTC 2007

Analysis of the CD33-related siglec family reveals that Siglec-9 is an endocytic receptor expressed on subsets of acute myeloid leukemia cells and absent from normal hematopoietic progenitors.

Leukemia research

Biedermann B,Gil D,Bowen DT,Crocker PR

MA1-19316 was used in flow cytometry to assess the use of CD33-related siglecs as markers of acute myeloid leukemia

Thu Feb 01 00:00:00 UTC 2007

The JAK2 V617F mutation occurs in hematopoietic stem cells in polycythemia vera and predisposes toward erythroid differentiation.

Proceedings of the National Academy of Sciences of the United States of America

Jamieson CH,Gotlib J,Durocher JA,Chao MP,Mariappan MR,Lay M,Jones C,Zehnder JL,Lilleberg SL,Weissman IL

MA1-19316 was used in flow cytometry to detect the JAK2 V617F mutation in hematopoietic stem cells and their progeny in patients with polycythemia vera

Tue Apr 18 00:00:00 UTC 2006

Multilineage engraftment of refrozen cord blood hematopoietic progenitors in NOD/SCID mice.

Haematologica

Timeus F,Crescenzio N,Sanavio F,Fazio L,Doria A,Foglia L,Pignochino Y,Berger M,Piacibello W,Madon E,Cordero di Montezemolo L,Fagioli F

MA1-19316 was used in flow cytometry assess the capacity of cord blood stem cells to repopulate irradiated NOD/SCID mice after cryopreservation

Wed Mar 01 00:00:00 UTC 2006

Diversity of the Ig repertoire is maintained with age in spite of reduced germinal centre cells in human tonsil lymphoid tissue.

Scandinavian journal of immunology

Kolar GR,Mehta D,Wilson PC,Capra JD

MA1-19316 was used in flow cytometry to study how the human VH4 immunoglobulin repertoire changes with age

Fri Sep 01 00:00:00 UTC 2006

The thrombopoietin receptor, c-Mpl, is a selective surface marker for human hematopoietic stem cells.

Journal of translational medicine

Ninos JM,Jefferies LC,Cogle CR,Kerr WG

MA1-19316 was used in flow cytometry to discuss the roles of thrombopoietin and c-mpl in hematopoiesis

Thu Feb 16 00:00:00 UTC 2006

Contemporaneous fluctuations in T cell responses to persistent herpes virus infections.

European journal of immunology

Crough T,Burrows JM,Fazou C,Walker S,Davenport MP,Khanna R

MA1-19316 was used in flow cytometry to show that T cell expansion and contractions in persistent viral infections is not limited to the acute phase of infection, but continues in latent infection

Sat Jan 01 00:00:00 UTC 2005

Role for granulocyte colony-stimulating factor in the generation of human T regulatory type 1 cells.

Blood

Rutella S,Pierelli L,Bonanno G,Sica S,Ameglio F,Capoluongo E,Mariotti A,Scambia G,d'Onofrio G,Leone G

MA1-19316 was used in flow cytometry to measure interleukin-10 and transforming growth factor-beta1 produced by T cells from healthy volunteer donors treated with recombinant human G-CSF.

Tue Oct 01 00:00:00 UTC 2002

Phosphatidylinositol 3-kinases are involved in the all-trans retinoic acid-induced upregulation of CD38 antigen on human haematopoietic cells.

British journal of haematology

Lewandowski D,Linassier C,Iochmann S,Degenne M,Domenech J,Colombat P,Binet C,Hérault O

MA1-19316 was used in flow cytometry to test if phosphoinositide 3-kinase is involved in the modification of CD38 antigen expression on myeloid cells.

Thu Aug 01 00:00:00 UTC 2002

Tropism of varicella-zoster virus for human tonsillar CD4(+) T lymphocytes that express activation, memory, and skin homing markers.

Journal of virology

Ku CC,Padilla JA,Grose C,Butcher EC,Arvin AM

MA1-19316 was used in flow cytometry to report that Varicella-zoster virus infects human tonsillar CD4(+) T cells.

Fri Nov 01 00:00:00 UTC 2002

Expression of CD41 and c-mpl does not indicate commitment to the megakaryocyte lineage during haemopoietic development.

British journal of haematology

Basch RS,Zhang XM,Dolzhanskiy A,Karpatkin S

MA1-19316 was used in flow cytometry to report that the expression of CD41 and c-mpl were not predictive of commitment to the megakaryocyte lineage.

Tue Jun 01 00:00:00 UTC 1999

Normal and clonal B lineage cells can be distinguished by their differential expression of B cell antigens and adhesion molecules in peripheral blood from multiple myeloma (MM) patients--diagnostic and clinical implications.

Clinical and experimental immunology

Luque R,Brieva JA,Moreno A,Manzanal A,Escribano L,Villarrubia J,Velasco JL,López-Jiménez J,Cerveró C,Otero MJ,Martínez J,Bellas C,Roldán E

MA1-19316 was used in flow cytometry to study the origin of peripheral blood B cells in patients with MM.

Mon Jun 01 00:00:00 UTC 1998

Is in vitro expansion of human cord blood cells clinically relevant?

Bone marrow transplantation

Denning-Kendall PA,Nicol A,Horsley H,Donaldson C,Bradley B,Hows JM

MA1-19316 was used in flow cytometry to elucidate factors that could prompt early peripheral blood recovery after cord blood transplantation.

Sun Feb 01 00:00:00 UTC 1998

生物信息学

蛋白别名: 2'-phospho-ADP-ribosyl cyclase; 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase; 2'-phospho-cyclic-ADP-ribose transferase; ADP-ribosyl cyclase 1; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; ADPRC 1; cADPr hydrolase 1; CD38; CD38 antigen (p45); CD38 antigen p45; cluster of differentiation 38; Cyclic ADP-ribose hydrolase 1; ecto-nicotinamide adenine dinucleotide glycohydrolase; NAD(+) nucleosidase; NAD+ nucleosidase; T10

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基因别名: ADPRC 1; ADPRC1; CD38

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UniProt ID: (Human) P28907

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Entrez Gene ID: (Human) 952

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功能

NAD+ nucleosidase activity transferase activity phosphorus-oxygen lyase activity NAD(P)+ nucleosidase activity

参与通路