Invitrogen

CD4 Monoclonal Antibody (RPA-T4)

CD4 Antibody in Immunocytochemistry (ICC/IF)

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CD4 Antibody (07-0403) in ICC/IF

The Journal of neuroscience : the official journal of the Society for Neuroscience 2002 - Published figure using CD4 monoclonal antibody (Product # 07-0403) in Immunocytochemistry

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产品信息

07-0403

应用

建议稀释比

已发表文章

免疫组化 (IHC)

查看1篇已发表文章 1篇已发表文章

免疫组化（冰冻） (IHC (F))

Assay-dependent

免疫细胞化学 (ICC/IF)

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流式细胞分析 (Flow)

Assay-dependent

查看14篇已发表文章 14篇已发表文章

免疫沉淀 (IP)

Assay-dependent

其他PubMed (Misc)

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产品规格

种属反应

Human

已发表种属

Human, Rat

宿主/亚型

Mouse / IgG1, kappa

分类

Monoclonal

类型

Antibody

克隆号

RPA-T4

抗原

Folded protein domain corresponding to the human CD4

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

purified

保存液

PBS

内含物

0.1% sodium azide

保存条件

-80°C

运输条件

Dry ice

AB_2532976

靶标信息

The CD4 antigen is involved in the recognition of MHC class II molecules and is a co-receptor for HIV. CD4 is primarily expressed in a subset of T-lymphocytes, also referred to as T helper cells, but may also be expressed by other cells in the immune system, such as monocytes, macrophages, and dendritic cells. At the tissue level, CD4 expression may be detected in thymus, lymph nodes, tonsils, and spleen, and also in specific regions of the brain, gut, and other non-lymphoid tissues. CD4 functions to initiate or augment the early phase of T-cell activation through its association with the T-cell receptor complex and protein tyrosine kinase, Lck. It may also function as an important mediator of direct neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcripts have been identified in this gene [RefSeq, July 2017].

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Targeting type I interferon-mediated activation restores immune function in chronic HIV infection.

The Journal of clinical investigation

Zhen A,Rezek V,Youn C,Lam B,Chang N,Rick J,Carrillo M,Martin H,Kasparian S,Syed P,Rice N,Brooks DG,Kitchen SG

07-0403 was used in flow cytometry to study the restoration of immune function in chronic HIV infection

Tue Jan 03 00:00:00 UTC 2017

Casein kinase 2 controls the survival of normal thymic and leukemic γδ T cells via promotion of AKT signaling.

Leukemia

Ribeiro ST,Tesio M,Ribot JC,Macintyre E,Barata JT,Silva-Santos B

70403 was used in flow cytometry to identify a role for CK2 in healthy human thymocytes in the selection of the gamma delta T-cell lineage

Sat Jul 01 00:00:00 UTC 2017

Caffeine induces gastric acid secretion via bitter taste signaling in gastric parietal cells.

Proceedings of the National Academy of Sciences of the United States of America

Liszt KI,Ley JP,Lieder B,Behrens M,Stöger V,Reiner A,Hochkogler CM,Köck E,Marchiori A,Hans J,Widder S,Krammer G,Sanger GJ,Somoza MM,Meyerhof W,Somoza V

07-0403 was used in Flow cytometry/Cell sorting to demonstrate that the route of application of caffeine determines its effects on gastric acid secretion in healthy human subjects.

Tue Jul 25 00:00:00 UTC 2017

Low-dose interleukin-2 promotes STAT-5 phosphorylation, T_reg survival and CTLA-4-dependent function in autoimmune liver diseases.

Clinical and experimental immunology

Jeffery HC,Jeffery LE,Lutz P,Corrigan M,Webb GJ,Hirschfield GM,Adams DH,Oo YH

70403 was used in flow cytometry to examine the potential of IL-2 to enhance T regulatory cell therapy

Thu Jun 01 00:00:00 UTC 2017

Differences in Peripheral Blood Lymphocytes between Brand-Name and Generic Tacrolimus Used in Stable Liver Transplant Recipients.

Medical principles and practice : international journal of the Kuwait University, Health Science Centre

Kim JM,Kwon CHD,Joh JW,Sinn DH,Choi GS,Park JB,Kang ES,Lee SK

70403 was used in flow cytometry to characterize the periferal blood lymphocytes phenotype in tacrolimus-treated liver transplanted patients.

Mon Mar 19 00:00:00 UTC 2018

The RNA-Binding Protein, Polypyrimidine Tract-Binding Protein 1 (PTBP1) Is a Key Regulator of CD4 T Cell Activation.

PloS one

La Porta J,Matus-Nicodemos R,Valentín-Acevedo A,Covey LR

70403 was used in flow cytometry to investigate the role of polypyrimidine tract-binding protein 1 in CD4 T cell activation

Thu Jul 27 00:00:00 UTC 2017

PD-1+Tim-3+ CD8+ T Lymphocytes Display Varied Degrees of Functional Exhaustion in Patients with Regionally Metastatic Differentiated Thyroid Cancer.

Cancer immunology research

Severson JJ,Serracino HS,Mateescu V,Raeburn CD,McIntyre RC,Sams SB,Haugen BR,French JD

07-0403 was used in flow cytometry to describe the phenotype and functional potential of metastatic differentiated thyroid cancer-associated PD-1 positive T cells

Mon Jun 01 00:00:00 UTC 2015

Thymic HIV-2 infection uncovers posttranscriptional control of viral replication in human thymocytes.

Journal of virology

Nunes-Cabaço H,Matoso P,Foxall RB,Tendeiro R,Pires AR,Carvalho T,Pinheiro AI,Soares RS,Sousa AE

07-0403 was used in Flow Cytometry to assess the direct impact of HIV-2 infection on the human thymus.

Sun Feb 01 00:00:00 UTC 2015

Trained immunity in newborn infants of HBV-infected mothers.

Nature communications

Hong M,Sandalova E,Low D,Gehring AJ,Fieni S,Amadei B,Urbani S,Chong YS,Guccione E,Bertoletti A

70403 was used in flow cytometry to show that hepatitis B virus exposure in utero enhances immunity to bacterial infections

Wed Mar 25 00:00:00 UTC 2015

Transcriptional profile of tuberculosis antigen-specific T cells reveals novel multifunctional features.

Journal of immunology (Baltimore, Md. : 1950)

Arlehamn CL,Seumois G,Gerasimova A,Huang C,Fu Z,Yue X,Sette A,Vijayanand P,Peters B

70403 was used in flow cytometry to investigate the impact of CCR6(+)CXCR3(+)CCR4(-) cells in latent tuberculosis infection

Mon Sep 15 00:00:00 UTC 2014

Abelson virus transformation prevents TRAIL expression by inhibiting FoxO3a and NF-kappaB.

Molecules and cells

Wilson MK,McWhirter SM,Amin RH,Huang D,Schlissel MS

07-0403 was used in Flow Cytometry to study the requirement of the inhibition of NF-kappaB and FoxO3a activity for the suppression of TRAIL transcription and maintenance of the transformed state.

Thu Apr 01 00:00:00 UTC 2010

Mature dendritic cells in inflamed human pulps beneath deep caries.

Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics

Harmon MA,Tew JG,Best AM,Hahn CL

07-0403 was used in immunohistochemistry to test if the frequency of CD83+ mature DCs correlates with caries invasion

Fri May 01 00:00:00 UTC 2009

Etiological treatment during early chronic indeterminate Chagas disease incites an activated status on innate and adaptive immunity associated with a type 1-modulated cytokine pattern.

Microbes and infection

Sathler-Avelar R,Vitelli-Avelar DM,Massara RL,de Lana M,Pinto Dias JC,Teixeira-Carvalho A,Elói-Santos SM,Martins-Filho OA

07-0403 was used in flow cytometry to assess the immunological status after Bz-treatment during early indeterminate Chagas disease

Fri Feb 01 00:00:00 UTC 2008

Activation/modulation of adaptive immunity emerges simultaneously after 17DD yellow fever first-time vaccination: is this the key to prevent severe adverse reactions following immunization?

Clinical and experimental immunology

Martins MA,Silva ML,Marciano AP,Peruhype-Magalhães V,Eloi-Santos SM,Ribeiro jG,Correa-Oliveira R,Homma A,Kroon EG,Teixeira-Carvalho A,Martins-Filho OA

07-0403 was used in flow cytometry to characterize the kinetics of the adaptive immune response following primary 17DD vaccination in order to clarify how it elicits such broad protection