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CD41 Antibody (MA5-44030) in Flow
Separation of murine CD41 positive thrombocytes (red-filled) from CD41 negative cells (black-dashed) in flow cytometry analysis (surface staining) of murine blood stained using anti-mouse CD41 (MWReg30) purified Monoclonal antibody (Product # MA5-44030), concentration in sample 0.6 µg/mL, GAM APC.
产品信息
MA5-44030
应用
建议稀释比
已发表文章
产品规格
种属反应
Mouse
宿主/亚型
Rat
/ IgG1, kappa
分类
Monoclonal
类型
Antibody
克隆号
MWReg30
抗原
Murine platelets
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein G
保存液
PBS, pH 7.4
内含物
15mM sodium azide
保存条件
4° C, do not freeze
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2912962
产品详细信息
This antibody recognizes an extracellular epitope of CD41 (GPIIb), a transmembrane glycoprotein (integrin family) composed of two chains GPIIb alpha (heavy chain; 120 kDa) and GPIIb beta (light chain; 23 kDa). CD41 is mainly expressed on platelets and megakaryocytes.
靶标信息
CD41 (platelet glycoprotein IIb, ITGA2B) is composed of two subunits -120 kDa a, alpha and 23 kDa b, beta- that interact with CD61 in the presence of calcium to form a functional adhesive protein receptor. CD41 is also involved in blood coagulation by mediating platelet aggregation. Upon blood vessel damage, CD41 binds to a variety of proteins including von Willebrand factor, fibrinogen, fibronectin and vitronectin. CD41 is mainly expressed on megakaryocyte-platelet lineage, but generally belongs to the antigens that are expressed during the early stages of hematopoietic differentiation. Diseases associated with CD41 dysfunction include Glansmann Thrombasthenia, and Platelet type-16 bleeding disorder.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: alpha IIb; CD41; form 1; form 2; GP IIb; GPalpha IIb; GPIIb; Integrin alpha-IIb; platelet glycoprotein IIb of IIb/II Ia complex; Platelet membrane glycoprotein IIb
基因别名: AI172977; alphaIIb; CD41; CD41B; GpIIb; Itga2b
UniProt ID: (Mouse) Q9QUM0
Entrez Gene ID: (Mouse) 16399
