Invitrogen

CD62L Monoclonal Antibody (MEL-14), APC

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CD62L Antibody (A14720) in Flow

Flow cytometry analysis of CD62L in BALB/c mouse splenocytes. Cells were stained using CD62L Monoclonal Antibody (MEL-14), APC (Product # A14720) and Rat Anti-Mouse CD3e-FITC.

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产品信息

A14720

应用

建议稀释比

已发表文章

流式细胞分析 (Flow)

0.1 µg/1x10^6 cells

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产品规格

种属反应

Mouse

已发表种属

Mouse

宿主/亚型

Rat / IgG2a, kappa

分类

Monoclonal

类型

Antibody

克隆号

MEL-14

抗原

C3H/eb mouse B-cell lymphoma, 38C13.

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偶联物

APC APC APC

激发/发射光谱

651/660 nm 查看光谱

形式

Liquid

浓度

0.1 mg/mL

纯化类型

purified

保存液

PBS, pH 7.5

内含物

<0.1% sodium azide

保存条件

4° C, store in dark, DO NOT FREEZE!

运输条件

Ambient (domestic); Wet ice (international)

AB_2534236

靶标信息

The human CD62L is a 74-95 kDa glycoprotein member of the selectin family of adhesion receptors. L-Selectin is comprised of an aminoterminal C-type lectin binding domain, an epidermal growth factor-like domain, two short consensus repeat (SCR) sequences homologous to those found in complement binding proteins, a short spacer region, a transmembrane region and a short cytoplasmic region. Human CD62L (L-Selectin) is constitutively expressed on all classes of leukocytes including lymphocytes (except a substantial population of memory T cells), monocytes and polymorphonuclear cells.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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Product References

Transcription factor RORα enforces stability of the Th17 cell effector program by binding to a Rorc cis-regulatory element.

Immunity

Hall JA,Pokrovskii M,Kroehling L,Kim BR,Kim SY,Wu L,Lee JY,Littman DR

A14720 was used in Flow cytometry/Cell sorting to demonstrate that although dispensable for Th17 cell differentiation, RORα was necessary for optimal Th17 responses in peripheral tissues.

Tue Nov 08 00:00:00 UTC 2022

Niche-Selective Inhibition of Pathogenic Th17 Cells by Targeting Metabolic Redundancy.

Cell

Wu L,Hollinshead KER,Hao Y,Au C,Kroehling L,Ng C,Lin WY,Li D,Silva HM,Shin J,Lafaille JJ,Possemato R,Pacold ME,Papagiannakopoulos T,Kimmelman AC,Satija R,Littman DR

A14720 was used in Flow Cytometry to suggest that inhibiting glycolysis by targeting Gpi1 could be an effective therapeutic strategy with minimum toxicity for Th17-mediated autoimmune diseases, and, more generally, that metabolic redundancies can be exploited for selective targeting of disease processes.

Thu Aug 06 00:00:00 UTC 2020

Serum Amyloid A Proteins Induce Pathogenic Th17 Cells and Promote Inflammatory Disease.

Cell

Lee JY,Hall JA,Kroehling L,Wu L,Najar T,Nguyen HH,Lin WY,Yeung ST,Silva HM,Li D,Hine A,Loke P,Hudesman D,Martin JC,Kenigsberg E,Merad M,Khanna KM,Littman DR

A14720 was used in Flow cytometry/Cell sorting to suggest that serum amyloid A proteins direct a pathogenic pro-inflammatory Th17 cell differentiation program and promote Th17-mediated inflammatory diseases.

Thu Jan 09 00:00:00 UTC 2020

Impairment of CCR6+ and CXCR3+ Th Cell Migration in HIV-1 Infection Is Rescued by Modulating Actin Polymerization.

Journal of immunology (Baltimore, Md. : 1950)

Cecchinato V,Bernasconi E,Speck RF,Proietti M,Sauermann U,D'Agostino G,Danelon G,Rezzonico Jost T,Grassi F,Raeli L,Schöni-Affolter F,Stahl-Hennig C,Uguccioni M

A14720 was used in flow cytometry to suggest that persistent immune activation causes impairment of lymphocytes to respond to chemotactic stimuli, preventing their trafficking from the blood stream to peripheral organs

Sun Jan 01 00:00:00 UTC 2017

Type I IFNs induce anti-tumor polarization of tumor associated neutrophils in mice and human.

International journal of cancer

Andzinski L,Kasnitz N,Stahnke S,Wu CF,Gereke M,von Köckritz-Blickwede M,Schilling B,Brandau S,Weiss S,Jablonska J

A14720 was used in flow cytometry to study the effects of IFN signaling on neutrophil polarization

Fri Apr 15 00:00:00 UTC 2016

生物信息学

蛋白别名: CD62 antigen-like family member L; CD62L; hLHRc; L-selectin; LAM-1; LECAM1; Leu-8; Leukocyte adhesion molecule 1; Leukocyte-endothelial cell adhesion molecule 1; Ly-22; Lymph node homing receptor; Lymphocyte antigen 22; Lymphocyte surface MEL-14 antigen

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基因别名: AI528707; CD62L; L-selectin; LECAM-1; Lnhr; Ly-22; Ly-m22; Ly22; Lyam-1; Lyam1; Sell

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UniProt ID: (Mouse) P18337

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Entrez Gene ID: (Mouse) 20343

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功能

protease binding protein binding carbohydrate binding cell adhesion molecule binding glycolipid binding

参与通路

cell adhesion response to ATP regulation of apoptotic process positive regulation of neutrophil chemotaxis