Invitrogen

CD62L Monoclonal Antibody (MEL-14), APC-Cyanine7

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CD62L Antibody (A15409) in Flow

Flow cytometry analysis of CD62L in BALB/c mouse splenocytes. Cells were stained using CD62L Monoclonal Antibody (MEL-14), APC-Cyanine7 (Product # A15409) Rat Anti-Mouse CD3e-APC.

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产品信息

A15409

应用

建议稀释比

已发表文章

流式细胞分析 (Flow)

0.1 µg/1x10^6 cells

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体外检测 (IV)

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产品规格

种属反应

Mouse

已发表种属

Human, Insect, Mouse

宿主/亚型

Rat / IgG2a, kappa

分类

Monoclonal

类型

Antibody

克隆号

MEL-14

抗原

C3H/eb mouse B-cell lymphoma, 38C13.

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偶联物

APC-Cyanine7 APC-Cyanine7 APC-Cyanine7

激发/发射光谱

653/782 nm 查看光谱

形式

Liquid

浓度

0.1 mg/mL

纯化类型

purified

保存液

PBS, pH 7.1, with proprietary stabilizer

内含物

<0.1% sodium azide

保存条件

4° C, store in dark, DO NOT FREEZE!

运输条件

Ambient (domestic); Wet ice (international)

AB_2534422

靶标信息

The human CD62L is a 74-95 kDa glycoprotein member of the selectin family of adhesion receptors. L-Selectin is comprised of an aminoterminal C-type lectin binding domain, an epidermal growth factor-like domain, two short consensus repeat (SCR) sequences homologous to those found in complement binding proteins, a short spacer region, a transmembrane region and a short cytoplasmic region. Human CD62L (L-Selectin) is constitutively expressed on all classes of leukocytes including lymphocytes (except a substantial population of memory T cells), monocytes and polymorphonuclear cells.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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Product References

Synergistic PIM kinase and proteasome inhibition as a therapeutic strategy for MYC-overexpressing triple-negative breast cancer.

Cell chemical biology

Kunder R,Velyunskiy M,Dunne SF,Cho BK,Kanojia D,Begg L,Orriols AM,Fleming-Trujillo E,Vadlamani P,Vialichka A,Bolin R,Perrino JN,Roth D,Clutter MR,Zielinski-Mozny NA,Goo YA,Cristofanilli M,Mendillo ML,Vassilopoulos A,Horiuchi D

A15409 was used in In vitro Assay to investigate the treatment of triple-negative breast cancer (TNBC) with elevated MYC expression, revealing that combining PIM inhibitors with proteasome inhibitors induces significant antitumor effects.

Thu Mar 17 00:00:00 UTC 2022

DJ-1 is not a deglycase and makes a modest contribution to cellular defense against methylglyoxal damage in neurons.

Journal of neurochemistry

Mazza MC,Shuck SC,Lin J,Moxley MA,Termini J,Cookson MR,Wilson MA

A15409 was used in flow cytometry experiments to suggest that DJ-1 is not a deglycase and has only a minor role in protecting neurons against methylglyoxal toxicity.

Mon Aug 01 00:00:00 UTC 2022

Quantification of Methylglyoxal Levels in Cowpea Leaves in Response to Cowpea Aphid Infestation.

Bio-protocol

MacWilliams JR,Ostaszewska-Bugajska M,Borysiuk K,Szal B,Kaloshian I

A15409 was used in Flow Cytometry to measure methylglyoxal in cowpea leaves after cowpea aphid infestation, by utilizing a perchloric acid extraction process.

Tue Oct 20 00:00:00 UTC 2020

The chemokine receptor CCR7 is a promising target for rheumatoid arthritis therapy.

Cellular & molecular immunology

Moschovakis GL,Bubke A,Friedrichsen M,Ristenpart J,Back JW,Falk CS,Kremmer E,Förster R

A15409 was used in Flow Cytometry to demonstrate that CCR7 signaling is essential for the induction of CIA and identify CCR7 as a potential therapeutic target in RA.

Tue Oct 01 00:00:00 UTC 2019

STAT6 Mediates Footpad Immunopathology in the Absence of IL-12p40 Following Infection of Susceptible BALB/c Mice With Leishmania major.

Frontiers in immunology

Kauffmann F,Meert E,de Jonge K,Elkrim Y,Hanot Mambres D,Denis O,Muraille E,Magez S,De Trez C

A15409 was used in Flow cytometry/Cell sorting to refine the role of IL-12p40 cytokine.

Fri May 10 00:00:00 UTC 2019

Impairment of CCR6+ and CXCR3+ Th Cell Migration in HIV-1 Infection Is Rescued by Modulating Actin Polymerization.

Journal of immunology (Baltimore, Md. : 1950)

Cecchinato V,Bernasconi E,Speck RF,Proietti M,Sauermann U,D'Agostino G,Danelon G,Rezzonico Jost T,Grassi F,Raeli L,Schöni-Affolter F,Stahl-Hennig C,Uguccioni M

A15409 was used in flow cytometry to suggest that persistent immune activation causes impairment of lymphocytes to respond to chemotactic stimuli, preventing their trafficking from the blood stream to peripheral organs

Sun Jan 01 00:00:00 UTC 2017

Type I IFNs induce anti-tumor polarization of tumor associated neutrophils in mice and human.

International journal of cancer

Andzinski L,Kasnitz N,Stahnke S,Wu CF,Gereke M,von Köckritz-Blickwede M,Schilling B,Brandau S,Weiss S,Jablonska J

A15409 was used in flow cytometry to study the effects of IFN signaling on neutrophil polarization

Fri Apr 15 00:00:00 UTC 2016

Studies of the metabotropic glutamate receptor 5 radioligand [¹¹C]ABP688 with N-acetylcysteine challenge in rhesus monkeys.

Synapse (New York, N.Y.)

Sandiego CM,Nabulsi N,Lin SF,Labaree D,Najafzadeh S,Huang Y,Cosgrove K,Carson RE

A15409 was used in flow cytometry to investigate the findings of a recent pilot study in baboons which reported a significant global decrease from baseline [C]ABP688 binding after increasing endogenous glutamate with 50 mg/kg N-acetylcysteine (NAC), with no change from test to retest.

Thu Aug 01 00:00:00 UTC 2013

生物信息学

蛋白别名: CD62 antigen-like family member L; CD62L; hLHRc; L-selectin; LAM-1; LECAM1; Leu-8; Leukocyte adhesion molecule 1; Leukocyte-endothelial cell adhesion molecule 1; Ly-22; Lymph node homing receptor; Lymphocyte antigen 22; Lymphocyte surface MEL-14 antigen

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基因别名: AI528707; CD62L; L-selectin; LECAM-1; Lnhr; Ly-22; Ly-m22; Ly22; Lyam-1; Lyam1; Sell

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UniProt ID: (Mouse) P18337

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Entrez Gene ID: (Mouse) 20343

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功能

protease binding protein binding carbohydrate binding cell adhesion molecule binding glycolipid binding

参与通路

cell adhesion response to ATP regulation of apoptotic process positive regulation of neutrophil chemotaxis