Invitrogen

CD69 Monoclonal Antibody (FN50)

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CD69 Antibody (MA1-10273) in Flow

Flow cytometry analysis (surface staining) of PHA-activated peripheral human blood using anti-CD69 antibody (clone FN50) purified Monoclonal antibody (Product # MA1-10273), GAM-APC.

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产品信息

MA1-10273

应用

建议稀释比

已发表文章

免疫组化（冰冻） (IHC (F))

Assay-Dependent

流式细胞分析 (Flow)

1-4 µg/mL

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其他PubMed (MISC)

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产品规格

种属反应

Human

已发表种属

Human

宿主/亚型

Mouse / IgG1

分类

Monoclonal

类型

Antibody

克隆号

FN50

抗原

anti-µ-stimulated human B lymphocytes

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A

保存液

PBS, pH 7.4

内含物

15mM sodium azide

保存条件

4° C, do not freeze

运输条件

Ambient (domestic); Wet ice (international)

AB_11154190

产品详细信息

This antibody recognizes an extracellular epitope of CD69, an lymphocyte early activation marker.

靶标信息

CD69 (AIM, Active Inducer Molecule) is a gp28/34 disulfide bonded homodimer with a molecular weight of 60 kDa under non-reducing conditions. CD69 contains one or two N linked oligosacaride and the molecule is present on activated platelets. In normal peripheral blood a variable percentage of cells express the CD69 antigen, and it is involved in lymphocyte signal transduction. Expression CD69 is induced upon activation of T lymphocytes, and may play a role in proliferation. Furthermore, the protein may act to transmit signals in natural killer cells and platelets. Alternative splicing results in multiple transcript variants of CD69. Diseases associated with CD69 dysfunction include coccidiodomycosis and asthma.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

A missense mutation in TFRC, encoding transferrin receptor 1, causes combined immunodeficiency.

Nature genetics

Jabara HH,Boyden SE,Chou J,Ramesh N,Massaad MJ,Benson H,Bainter W,Fraulino D,Rahimov F,Sieff C,Liu ZJ,Alshemmari SH,Al-Ramadi BK,Al-Dhekri H,Arnaout R,Abu-Shukair M,Vatsayan A,Silver E,Ahuja S,Davies EG,Sola-Visner M,Ohsumi TK,Andrews NC,Notarangelo LD,Fleming MD,Al-Herz W,Kunkel LM,Geha RS

MA110273 was used in flow cytometry to elucidate the role of TfR1 in adaptive immunity

Fri Jan 01 00:00:00 UTC 2016

Junctophilin-4, a component of the endoplasmic reticulum-plasma membrane junctions, regulates Ca2+ dynamics in T cells.

Proceedings of the National Academy of Sciences of the United States of America

Woo JS,Srikanth S,Nishi M,Ping P,Takeshima H,Gwack Y

MA1-10273 was used in flow cytometry to determine the composition of Orai1 channels found at the endoplasmic reticulum-plasma membrane junction

Tue Mar 08 00:00:00 UTC 2016

Strain-specific Plasmodium falciparum multifunctional CD4(+) T cell cytokine expression in Malian children immunized with the FMP2.1/AS02A vaccine candidate.

Vaccine

Graves SF,Kouriba B,Diarra I,Daou M,Niangaly A,Coulibaly D,Keita Y,Laurens MB,Berry AA,Vekemans J,Ripley Ballou W,Lanar DE,Dutta S,Gray Heppner D,Soisson L,Diggs CL,Thera MA,Doumbo OK,Plowe CV,Sztein MB,Lyke KE

MA110273 was used in flow cytometry to characterize the immune responses of children immunized with Plasmodium falciparum apical membrane antigen 1

Tue May 17 00:00:00 UTC 2016

The RNA-Binding Protein, Polypyrimidine Tract-Binding Protein 1 (PTBP1) Is a Key Regulator of CD4 T Cell Activation.

PloS one

La Porta J,Matus-Nicodemos R,Valentín-Acevedo A,Covey LR

MA110273 was used in flow cytometry to investigate the role of polypyrimidine tract-binding protein 1 in CD4 T cell activation

Thu Jul 27 00:00:00 UTC 2017

Evidence for the involvement of gamma delta T cells in the immune response in Rasmussen encephalitis.

Journal of neuroinflammation

Owens GC,Erickson KL,Malone CC,Pan C,Huynh MN,Chang JW,Chirwa T,Vinters HV,Mathern GW,Kruse CA

MA1-10273 was used in flow cytometry to discuss the role of T cells in Rasmussen encephalitis

Sun Jul 19 00:00:00 UTC 2015

Monocytes and the 38kDa-antigen of mycobacterium tuberculosis modulate natural killer cell activity and their cytolysis directed against ovarian cancer cell lines.

BMC cancer

Gottschalk N,Lang S,Kimmig R,Singh M,Brandau S

MA1-10273 was used in flow cytometry to assess the modulation of different natural killer cell functions by accessory monocytes and PstS-1

Thu Oct 04 00:00:00 UTC 2012

Early induction of polyfunctional simian immunodeficiency virus (SIV)-specific T lymphocytes and rapid disappearance of SIV from lymph nodes of sooty mangabeys during primary infection.

Journal of immunology (Baltimore, Md. : 1950)

Meythaler M,Wang Z,Martinot A,Pryputniewicz S,Kasheta M,McClure HM,O'Neil SP,Kaur A

MA1-10273 was used in flow cytometry to study the contribution of the cellular immune response in maintaining nonpathogenic SIV infection in sooty mangabeys.

Sun May 01 00:00:00 UTC 2011

生物信息学

蛋白别名: Activation inducer molecule; activation inducer molecule (AIM/CD69); AIM; BL-AC/P26; C-type lectin domain family 2 member C; C-type lectin domain family 2, member C; CD69; CD69 antigen (p60, early T-cell activation antigen); EA1; Early activation antigen CD69; early lymphocyte activation antigen; Early T-cell activation antigen p60; GP32/28; Leukocyte surface antigen Leu-23; MLR-3

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基因别名: AIM; BL-AC/P26; CD69; CLEC2C; EA1; GP32/28; MLR-3

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UniProt ID: (Human) Q07108

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Entrez Gene ID: (Human) 969

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功能

transmembrane signaling receptor activity calcium ion binding protein binding carbohydrate binding

参与通路

signal transduction cellular response to drug