Invitrogen

CD7 Monoclonal Antibody (CD7-6B7), APC

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CD7 Antibody (MHCD0705) in Flow

Antigen Specificity: According to the literature this antibody recognizes the CD7 antigen. CD7 is expressed on thymocytes, T cells, pre-B cells and NK cells.

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产品信息

MHCD0705

应用

建议稀释比

已发表文章

流式细胞分析 (Flow)

Assay-Dependent

查看6篇已发表文章 6篇已发表文章

产品规格

种属反应

Human

已发表种属

Human, Mouse

宿主/亚型

Mouse / IgG2a

分类

Monoclonal

类型

Antibody

克隆号

CD7-6B7

抗原

Human CD7

偶联物

APC APC APC

激发/发射光谱

651/660 nm 查看光谱

形式

Liquid

纯化类型

purified

保存液

PBS with 4mg/mL BSA, sucrose

内含物

0.1% sodium azide

保存条件

4° C, store in dark

运输条件

Ambient (domestic); Wet ice (international)

AB_10375171

产品详细信息

Allophycocyanin (APC) is a stable and highly soluble phycobiliprotein that provides maximal absorbance and fluorescence without susceptibility to internal or external fluorescence quenching, thus providing exceptional quantum yields and molar extinction coefficients.

靶标信息

CD7 (gp40, Leu9) is a 40 kDa member of the immunoglobulin gene superfamily. CD7 contains N-terminal amino acids 1-107 are highly homologous to Ig kappa-L chains whereas the carboxy-terminal region of the extracellular domain is proline-rich and has been postulated to form a stalk from which the Ig domain projects. CD7 is expressed on the majority of immature and mature T-lymphocytes, and T cell leukemia. Further, CD7 is also found on natural killer cells, a small subpopulation of normal B cells and on malignant B cells. Cross-linking surface CD7 positively modulates T cell and NK cell activity as measured by calcium fluxes, expression of adhesion molecules, cytokine secretion and proliferation. CD7 associates directly with phosphoinositol 3'-kinase. CD7 ligation induces production of D-3 phosphoinositides and tyrosine phosphorylation. Expression of CD7 is an important marker used in leukemia diagnostics.

Analyte Specific Reagent

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Product References

Frequent and reliable engraftment of certain adult primary acute lymphoblastic leukemias in mice.

Leukemia & lymphoma

Heckl BC,Carlet M,Vick B,Roolf C,Alsadeq A,Grunert M,Liu WH,Liebl A,Hiddemann W,Marschalek R,Schewe DM,Spiekermann K,Junghanss C,Jeremias I

MHCD0705 was used in Flow cytometry/Cell sorting to show that primary adult acute lymphoblastic leukemias cells of two discrete high-risk cytogenetic groups reliably engraft in mice at high frequencies.

Fri Mar 01 00:00:00 UTC 2019

Characterization and Purification of Neoplastic Cells of Nodular Lymphocyte Predominant Hodgkin Lymphoma from Lymph Nodes by Flow Cytometry and Flow Cytometric Cell Sorting.

The American journal of pathology

Fromm JR,Thomas A,Wood BL

MHCD0705 was used in flow cytometry to document and describe lymphocyte predominant cells from lymph nodes involved in nodular lymphocyte predominant Hodgkin lymphoma

Wed Feb 01 00:00:00 UTC 2017

Reactive T cells by flow cytometry distinguish Hodgkin lymphomas from T cell/histiocyte-rich large B cell lymphoma.

Cytometry. Part B, Clinical cytometry

Wu D,Thomas A,Fromm JR

MHCD0705 was used in flow cytometry to discuss using the infiltrate to diagnosis B-cell lymphomas.

Thu Sep 01 00:00:00 UTC 2016

Flow cytometry of ALK-negative anaplastic large cell lymphoma of breast implant-associated effusion and capsular tissue.

Cytometry. Part B, Clinical cytometry

Wu D,Allen CT,Fromm JR

MHCD0705 was used in flow cytometry to characterize two cases of anaplastic large cell lymphoma using flow cytometry.

Thu Jan 01 00:00:00 UTC 2015

Generation of human acute lymphoblastic leukemia xenografts for use in oncology drug discovery.

Current protocols in pharmacology

Holmfeldt L,Mullighan CG

MHCD0705 was used in flow cytometry to describe procedures to establish and maintain primary acute lymphoblastic leukemia xenograft panels

Mon Mar 02 00:00:00 UTC 2015

Flow cytometry significantly improves the diagnostic value of fine needle aspiration cytology of lymphoproliferative lesions of salivary glands.

Cytopathology : official journal of the British Society for Clinical Cytology

Stacchini A,Aliberti S,Pacchioni D,Demurtas A,Isolato G,Gazzera C,Veltri A,Maletta F,Molinaro L,Novero D

MHCD0705 was used in flow cytometry to compare fine needle aspiration cytology with flow cytometry immunophenotyping for the diagnosis of lymphoproliferative processes in the salivary glands.