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CD74 Chimeric Antibody (MA5-48091) in ICC/IF
Immunocytochemistry/Immunofluorescence analysis of CD74 in mouse splenocytes using CD74 Chimeric Monoclonal Antibody (Product # MA5-48091). Paraformaldehyde-fixed cells were immobilized on cover slips and stained with CD74 Chimeric Monoclonal Antibody at 10 µg/mL for 1h followed by Alexa Fluor488 secondary antibody (1 µg/mL), showing membrane staining. The nuclear stain is DAPI (blue). Panels show from left... View More
产品信息
MA5-48091
应用
建议稀释比
已发表文章
产品规格
种属反应
Mouse
宿主/亚型
Rabbit
/ IgG, kappa
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
In-1
抗原
Mouse lymphocytes of strain A injected into Wistar rats.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS
内含物
0.02% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_3074534
产品详细信息
Specificity: This antibody binds to murine CD74.
靶标信息
HLA-DR, like other MHC class II molecules, is a transmembrane glycoprotein composed of a 36 kDa alpha chain (DRA) and 27 kDa beta chain (DRB). The alpha chain gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. HLA-DR is expressed primarily on antigen presenting cells such as B lymphocytes, monocytes, macrophages, thymic epithelial cells and activated T lymphocytes. Three loci, DR, DQ and DP, encode the major expressed products of the human class II region. The human MHC class II molecules bind intracellularly processed peptides, present them to T-helper cells, and have a critical role in the initiation of the immune response.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CD74; CD74 antigen; class II-associated invariant chain peptide; dinucleotide microsatellite; H-2 class II histocompatibility antigen gamma chain; histocompatibility: class II antigens, gamma chain of; HLA-DR-GAMMA; Ia antigen-associated invariant chain; Ia-associated invariant chain; Ii; invariant polypeptide of major histocompatibility complex, class II antigen-associated; MHC class II-associated invariant chain
基因别名: Cd74; CLIP; DHLAG; HLADG; Ia-GAMMA; Ii
UniProt ID: (Mouse) P04441
Entrez Gene ID: (Mouse) 16149
beta-amyloid binding
cytokine receptor activity
protein binding
cytokine binding
MHC class II protein complex binding
macrophage migration inhibitory factor binding
MHC class II protein binding
MHC class II protein binding, via antigen binding groove
protein binding involved in protein folding
nitric-oxide synthase binding
scaffold/adaptor protein
activation of MAPK activity
prostaglandin biosynthetic process
positive regulation of cytokine-mediated signaling pathway
immune system process
positive regulation of dendritic cell antigen processing and presentation
negative regulation of peptide secretion
positive regulation of adaptive immune response
positive regulation of type 2 immune response
negative regulation of mature B cell apoptotic process
protein folding
protein complex assembly
intracellular protein transport
defense response
immune response
signal transduction
cell proliferation
immunoglobulin mediated immune response
cytokine-mediated signaling pathway
antigen processing and presentation
antigen processing and presentation of exogenous peptide antigen via MHC class II
positive regulation of B cell proliferation
macrophage migration inhibitory factor signaling pathway
negative regulation of apoptotic process
negative regulation of DNA damage response, signal transduction by p53 class mediator
positive thymic T cell selection
negative thymic T cell selection
positive regulation of innate immune response
negative regulation of T cell differentiation
positive regulation of T cell differentiation
positive regulation of fibroblast proliferation
positive regulation of peptidyl-tyrosine phosphorylation
chaperone mediated protein folding requiring cofactor
positive regulation of macrophage cytokine production
positive regulation of ERK1 and ERK2 cascade
positive regulation of neutrophil chemotaxis
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
positive regulation of chemokine (C-X-C motif) ligand 2 production
