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CD88 (C5aR1) Antibody (12-0888-42) in Flow
Human lysed whole blood was surface stained with CD11b Monoclonal Antibody, APC (Product # 17-0118-42) and Mouse IgG2a kappa Isotype Control, PE (Product # 12-4724-82) (left) or CD88 (C5aR1) Monoclonal Antibody, PE (right). Total viable cells were used for analysis, as determined by Fixable Viability Dye eFluor 450 (Product # 65-0863-18).
产品信息
12-0888-42
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2a, kappa
分类
Monoclonal
类型
Antibody
克隆号
S5/1
抗原
BSA-Conjugated Peptide aa. 1-31
偶联物
激发/发射光谱
565/576 nm
查看光谱
形式
Liquid
浓度
5 µL/Test
纯化类型
Affinity chromatography
保存液
PBS, pH 7.2, with 0.2% BSA
内含物
0.09% sodium azide
保存条件
4° C, store in dark, DO NOT FREEZE!
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2815041
产品详细信息
Description: This S5/1 monoclonal antibody recognizes human CD88 also known as C5aR1. C5aR1 is a complement receptor widely expressed on cells of the myeloid lineage. Clone S5/1 has been reported to block C5a binding.
Applications Reported: This S5/1 antibody has been reported for use in flow cytometric analysis.
Applications Tested: This S5/1 antibody has been pre-diluted and tested by flow cytometric analysis of normal human peripheral blood cells. This may be used at 5 µL (0.25 µg) per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test.
Excitation: 488-561 nm; Emission: 578 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser
靶标信息
CD88, also known as C5aR1, is a C5a Anaphylatoxin Receptor that mediates the effects of one of the most potent chemotactic agents known. C5AR1 has been implicated in asthma, and its expression has been reported in myeloid blood cells, brain, liver, lung, spleen, heart, kidney, and intestinal tract. CD88 is the receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. Functionally, CD88 stimulates chemotaxis, granule enzyme release and superoxide anion production. CD88 is also a component of the classical pathway of the complement cascade; it may be involved with tissue injury associated with ischemia or sepsis and it may be a component of the membrane attack complex. Diseases associated with CD88 include Mannose-Binding Lectin Deficiency and Systemic Lupus Erythematosus.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
How to use the Panel Builder
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生物信息学
蛋白别名: C5a anaphylatoxin chemotactic receptor; C5a anaphylatoxin chemotactic receptor 1; C5a anaphylatoxin receptor; C5a ligand; C5a Receptor; C5a-R; CD88; CD88 antigen; complement component 5 receptor 1
基因别名: C5A; C5AR; C5AR1; C5R1; CD88
UniProt ID: (Human) P21730
Entrez Gene ID: (Human) 728
activation of MAPK activity
apoptotic process
chemotaxis
inflammatory response
immune response
cellular defense response
signal transduction
activation of phospholipase C activity
positive regulation of cytosolic calcium ion concentration
sensory perception of chemical stimulus
positive regulation of vascular endothelial growth factor production
positive regulation of macrophage chemotaxis
cell proliferation in hindbrain
regulation of complement activation
neutrophil chemotaxis
organ regeneration
response to peptidoglycan
response to lipopolysaccharide
complement component C5a signaling pathway
mRNA transcription from RNA polymerase II promoter
negative regulation of neuron apoptotic process
positive regulation of angiogenesis
positive regulation of epithelial cell proliferation
defense response to Gram-positive bacterium
positive regulation of ERK1 and ERK2 cascade
positive regulation of neutrophil chemotaxis
