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CD98 Antibody (PA5-96401) in IHC (P)
Immunohistochemistry analysis of CD98 in paraffin-embedded human placenta. Samples were incubated with CD98 Polyclonal antibody (Product # PA5-96401) using a dilution of 1:50 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.
产品信息
PA5-96401
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 206-630 of human SLC3A2/CD98hc (NP_002385.3).
偶联物
形式
Liquid
浓度
1.66 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2808203
产品详细信息
Immunogen sequence: RAPRCRELPA QKWWHTGALY RIGDLQAFQG HGAGNLAGLK GRLDYLSSLK VKGLVLGPIH KNQKDDVAQT DLLQIDPNFG SKEDFDSLLQ SAKKKSIRVI LDLTPNYRGE NSWFSTQVDT VATKVKDALE FWLQAGVDGF QVRDIENLKD ASSFLAEWQN ITKGFSEDRL LIAGTNSSDL QQILSLLESN KDLLLTSSYL SDSGSTGEHT KSLVTQYLNA TGNRWCSWSL SQARLLTSFL PAQLLRLYQL MLFTLPGTPV FSYGDEIGLD AAALPGQPME APVMLWDESS FPDIPGAVSA NMTVKGQSED PGSLLSLFRR LSDQRSKERS LLHGDFHAFS AGPGLFSYIR HWDQNERFLV VLNFGDVGLS AGLQASDLPA SASLPAKADL LLSTQPGREE GSPLELERLK LEPHEGLLLR FPYAA
Positive Samples: 293T, MCF7, SW480, SKOV3, Mouse kidney, Mouse lung, Mouse testis, Mouse ovary; Cellular Location: Apical cell membrane, Melanosome, Single-pass type II membrane protein
靶标信息
CD98 (4F2) is a type II transmembrane glycoprotein which serves as the heavy chain of the heterodimeric amino acid transporters (HATs). CD98, linked to various light chains by disulfide bond, is responsible for cell surface expression and basolateral localization of this transporter complex in polarized epithelial cells and also interacts with beta1 integrins and increases their affinity for ligand. Besides its roles in amino acid transport, CD98 is thus involved in cell fusion and activation. It is implicated in regulation of cellular differentiation, growth and apoptosis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: 4F2 cell-surface antigen heavy chain; 4F2 heavy chain antigen; 4F2hc; Amino acid transporter heavy chain SLC3A2; antigen defined by monoclonal antibody 4F2, heavy chain; antigen identified by monoclonal antibodies 4F2; antigen identified by monoclonal antibodies 4F2, TRA1.10, TROP4, and T43; CD98; CD98 antigen; CD98 heavy chain; Lymphocyte activation antigen 4F2 large subunit; monoclonal antibody 44D7; slc3a2 {ECO:0000312|RGD:3073}; solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2; solute carrier family 3 (amino acid transporter heavy chain), member 2; Solute carrier family 3 member 2; solute carrier family 3, member 2; type II transmembrane protein
基因别名: 4F2; 4F2HC; 4T2HC; AI314110; CD98; CD98HC; Ly-10; Ly-m10; Ly10; MDU1; Mgp-2hc; NACAE; SLC3A2
UniProt ID: (Human) P08195, (Mouse) P10852, (Rat) Q794F9
Entrez Gene ID: (Human) 6520, (Mouse) 17254, (Rat) 50567
