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CDC20 Antibody (IHC-00232) in IHC (P)
Detection of Human CDC20 by Immunohistochemistry. Sample: FFPE section of human breast carcinoma. Antibody: Affinity purified rabbit anti-CDC20 (Product # IHC-00232) used at a dilution of 1:250. Detection: DAB. staining using Immunohistochemistry Accessory Kit (Product # IHC-101).
产品信息
IHC-00232
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Region between residue 50 and 100 of human cell division cycle 20.
偶联物
形式
Liquid
浓度
0.50 mg/mL
纯化类型
Antigen affinity chromatography
保存液
TBS, pH 7.0 to 8.0, with 0.1% BSA
内含物
0.09% sodium azide
保存条件
4° C
运输条件
Wet ice
产品详细信息
The recommended shelf life for this product is 1 year from date of receipt.
Based on 100% sequence identity, this antibody is predicted to react with Dog, Horse, Guinea pig_10141, Pig, Panda, Orangutan, Monkey, Gorilla, Chimpanzee, Small-eared galago and Naked mole rat
靶标信息
Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CDC20 cell division cycle 20 homolog; cell division cycle 20 homolog; Cell division cycle protein 20 homolog; mmCdc20; p55CDC
基因别名: 2310042N09Rik; bA276H19.3; C87100; CDC20; CDC20A; p55CDC
UniProt ID: (Human) Q12834, (Mouse) Q9JJ66
Entrez Gene ID: (Human) 991, (Mouse) 107995
cell cycle
sister chromatid cohesion
mitotic nuclear division
positive regulation of cell proliferation
anaphase-promoting complex-dependent catabolic process
positive regulation of synaptic plasticity
regulation of meiotic nuclear division
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
proteasome-mediated ubiquitin-dependent protein catabolic process
regulation of dendrite development
cell division
negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
positive regulation of synapse maturation
positive regulation of ubiquitin protein ligase activity
nervous system development
cell differentiation
