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CDK11B Antibody (PA5-101091) in ICC/IF
Immunocytochemistry analysis of CDK11B in A549 cells. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25°C. Samples were incubated with CDK11B polyclonal antibody (Product # PA5-101091) and mouse anti-beta tubulin antibody for 1 hour at 37°C. An AlexaFluor594 conjugated goat anti-rabbit IgG(H+L) (Red) and an AlexaFluor488 conjugated goat anti-mouse IgG(H+L) (Green) were used as the secondary antibodies. The nuclear counter stain is DAPI (blue).
产品信息
PA5-101091
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human CDK11B(Accession P21127), corresponding to amino acid residues M1-E50.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2850535
产品详细信息
Antibody detects endogenous levels of total CDC2L1.
靶标信息
The PITSLRE beta1 protein, a distantly related member of the Cdk family of protein kinases, induces apoptosis after low levels of ectopic expression. Apoptosis, or programmed cell death, is similarly induced by ectopic expression of an amino terminal deletion mutant retaining the catalytic and carboxyterminal domains of PITSLRE beta1, but not by other mutants lacking Histone H1 kinase activity or by other Cdk family members. The terminology for the ten isoforms of the PITSLRE subfamily of proteins is based on the conserved PSTAIRE box region of Cdc2 p34. Depending on which of the PITSLRE genes produce the protein, the cDNA and protein are designated alpha, beta or gamma (i.e., PITSLRE A gene, alpha; PITSLRE B gene, beta and PITSLRE C gene, gamma). Some of the isoforms such as PITSLRE alpha1 (T cells) and PITSLRE beta1 (B cells and brain), are expressed in specific cell types, while others are expressed ubiquitously.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CDC-related protein kinase p58; CDC2L3; CDK11 p110; CDK11 p46; CDK11 p58; CDK11A; cell division cycle 2 homolog-like 1; cell division cycle 2 homolog-like 2; cell division cycle 2-like 1; cell division cycle 2-like 1 (PITSLRE proteins); cell division cycle 2-like 2; Cell division cycle 2-like protein kinase 1; Cell division protein kinase 11; Cell division protein kinase 11B; CLK-1; Cyclin-dependent kinase 11; Cyclin-dependent kinase 11B; Galactosyltransferase-associated protein kinase p58/GTA; p58 CLK-1; PITSLRE proteins; PITSLRE serine/threonine-protein kinase CDC2L1
基因别名: AA989746; Cdc11b; CDC2L1; Cdc2l2; CDK11; CDK11-p110; CDK11-p46; CDK11-p58; CDK11B; CLK-1; p58; p58CDC2L1; p58CLK-1; PITSLREA; PK58
UniProt ID: (Human) P21127, (Mouse) P24788
Entrez Gene ID: (Human) 984, (Mouse) 12537
protein kinase activity
protein serine/threonine kinase activity
cyclin-dependent protein serine/threonine kinase activity
protein binding
ATP binding
poly(A) RNA binding
nucleotide binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
regulation of cell growth
regulation of transcription, DNA-templated
protein phosphorylation
apoptotic process
mitotic nuclear division
cell proliferation
regulation of mRNA processing
regulation of cell cycle
blastocyst development
cell cycle
regulation of mitotic nuclear division
phosphorylation
negative regulation of apoptotic signaling pathway
