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CDK3/CyclinE1is a member of the cyclin-dependent protein kinase family and promotes entry into S phase, in part by activating members of the E2F family of transcription factors. CDK3 can also associate with cyclin C and phosphorylates the retinoblastoma 1 protein to promote exit from G0. The CDK3 gene has been mapped to chromosomal location of 17q22-qter, telomeric to the BRCA1 gene by somatic cell hybrids analysis. The presence of a single point mutation in the CDK3 gene from several Mus musculus strains commonly used in the laboratory has been reported.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Cell division protein kinase 3; Cyclin-dependent kinase 3
基因别名: CDK3; CDKN3
UniProt ID: (Human) Q00526
Entrez Gene ID: (Human) 1018