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CDK5 Antibody (H00001020-D01P) in WB
Western Blot analysis of CDK5 expression in transfected 293T cell line (H00001020-T02) by CDK5 MaxPab polyclonal antibody.
Lane 1: CDK5 transfected lysate(33.30 KDa).
Lane 2: Non-transfected lysate.
Lane 1: CDK5 transfected lysate(33.30 KDa).
Lane 2: Non-transfected lysate.
Product Details
H00001020-D01P
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CDK5 (NP_004926.1, 1 a.a. approximately 292 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
See Label
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: MQKYEKLEKI GEGTYGTVFK AKNRETHEIV ALKRVRLDDD DEGVPSSALR EICLLKELKH KNIVRLHDVL HSDKKLTLVF EFCDQDLKKY FDSCNGDLDP EIVKSFLFQL LKGLGFCHSR NVLHRDLKPQ NLLINRNGEL KLADFGLARA FGIPVRCYSA EVVTLWYRPP DVLFGAKLYS TSIDMWSAGC IFAELANAGR PLFPGNDVDD QLKRIFRLLG TPTEEQWPSM TKLPDYKPYP MYPATTSLVN VVPKLNATGR DLLQNLLKCN PVQRISAEEA LQHPYFSDFC PP
Target Information
CDK5 is a member of the Cyclin-Dependent Kinase family that is most abundant in the mammalian brain. Active form of CDK5, which has also been called neuronal cdc2-like kinase, is a heterodimer of CDK5 and a 25 kDa protein which is derived proteolytically from a 35 kDa brain and neuron-specific protein and is essential for the kinase activity of CDK5. CDK5 has emerged as a crucial regulator of neuronal migration in the developing central nervous system. CDK5 phosphorylates a diverse list of substrates, implicating it in the regulation of a range of cellular processes - from adhesion and motility, to synaptic plasticity and drug addiction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CDK5 activator 1; CDK5-SV; Cell division protein kinase 5; Cyclin-dependent kinase 5; Cyclin-dependent-like kinase 5; protein kinase CDK5 splicing; Serine/threonine-protein kinase PSSALRE; Tau protein kinase II catalytic subunit; TPKII catalytic subunit
Gene Aliases: CDK5; CDKN5; LIS7; PSSALRE
UniProt ID: (Human) Q00535
Entrez Gene ID: (Human) 1020
p53 binding
protein kinase activity
protein serine/threonine kinase activity
cyclin-dependent protein serine/threonine kinase activity
ErbB-2 class receptor binding
protein binding
ATP binding
cytoskeletal protein binding
kinase activity
protein kinase binding
acetylcholine receptor activator activity
ErbB-3 class receptor binding
ephrin receptor binding
tau-protein kinase activity
non-receptor serine/threonine protein kinase
neuron migration
synaptic transmission, dopaminergic
intracellular protein transport
nucleocytoplasmic transport
cell cycle
cell-matrix adhesion
chemical synaptic transmission
synapse assembly
skeletal muscle tissue development
motor neuron axon guidance
cell proliferation
visual learning
response to wounding
Schwann cell development
synaptic vesicle exocytosis
regulation of macroautophagy
phosphorylation
peptidyl-serine phosphorylation
peptidyl-threonine phosphorylation
sensory perception of pain
cerebellar cortex formation
hippocampus development
layer formation in cerebral cortex
central nervous system neuron development
corpus callosum development
neuron differentiation
regulation of cell migration
negative regulation of axon extension
cortical actin cytoskeleton organization
neuron projection development
negative regulation of protein ubiquitination
negative regulation of synaptic plasticity
positive regulation of protein binding
receptor catabolic process
serine phosphorylation of STAT3 protein
synaptic transmission, glutamatergic
protein localization to synapse
regulation of apoptotic process
receptor clustering
positive regulation of neuron apoptotic process
negative regulation of cell cycle
positive regulation of protein kinase activity
negative regulation of proteolysis
negative regulation of transcription, DNA-templated
positive regulation of calcium ion-dependent exocytosis
protein autophosphorylation
negative regulation of protein export from nucleus
behavioral response to cocaine
regulation of synaptic plasticity
synaptic vesicle endocytosis
rhythmic process
axon extension
oligodendrocyte differentiation
dendrite morphogenesis
cell division
neuron apoptotic process
excitatory postsynaptic potential
regulation of dendritic spine morphogenesis
calcium ion import
regulation of cell cycle arrest
positive regulation of protein targeting to membrane
negative regulation of neuron death
regulation of signal transduction by p53 class mediator
regulation of synaptic vesicle recycling
positive regulation of actin cytoskeleton reorganization
positive regulation of receptor activity
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