Invitrogen

CDK5 Polyclonal Antibody

查看其他23个CDK5抗体

抗体检测数据 (3)
高级验证 (1)

CDK5 Antibody in Immunocytochemistry (ICC/IF)

CDK5 Antibody in Immunocytochemistry (ICC/IF)

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CDK5 Antibody (PA5-84646) in ICC/IF

Immunofluorecent analysis of CDK5 in human cell line SH-SY5Y using CDK5 Polyclonal Antibody (Product # PA5-84646). Staining shows localization to nucleus and cytosol.

CDK5 Antibody in Immunocytochemistry (ICC/IF)

CDK5 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

CDK5 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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CDK5 Antibody in Immunocytochemistry (ICC/IF) — Immunofluorecent analysis of CDK5 in human cell line SH-SY5Y using CDK5 Polyclonal Antibody (Product # PA5-84646). Staining shows localization to nucleus and cytosol.

CDK5 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemical analysis of CDK5 in human pancreas using CDK5 Polyclonal Antibody (Product # PA5-84646) shows low expression as expected.

CDK5 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemical analysis of CDK5 in human cerebral cortex using CDK5 Polyclonal Antibody (Product # PA5-84646) shows high expression.

CDK5 Antibody — Relative expression in different tissues in IHC: Detection of differential expression levels of CDK5 demonstrates antibody specificity. Immunohistochemical analysis of CDK5 using anti-CDK5 Polyclonal Antibody (Product #PA5-84646), shows significant staining of CDK5 in cerebral cortex and shows minimal or weak staining in pancreas tissues. The relative expression levels of CDK5 within each tissue is shown using RNA-Seq. {RE}

产品信息

PA5-84646

应用

建议稀释比

已发表文章

免疫组化（石蜡） (IHC (P))

1:200-1:500

-

免疫细胞化学 (ICC/IF)

0.25-2 µg/mL

-

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant protein corresponding to Human CDK5. Recombinant protein control fragment (Product #RP-107340).

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.2, with 40% glycerol

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

AB_2791797

产品详细信息

Immunogen sequence: TEEQWPSMTK LPDYKPYPMY PATTSLVNVV PKLNATGRDL LQNLLKCNPV QRISAEEALQ HPYFSDFCP

靶标信息

CDK5 is a member of the Cyclin-Dependent Kinase family that is most abundant in the mammalian brain. Active form of CDK5, which has also been called neuronal cdc2-like kinase, is a heterodimer of CDK5 and a 25 kDa protein which is derived proteolytically from a 35 kDa brain and neuron-specific protein and is essential for the kinase activity of CDK5. CDK5 has emerged as a crucial regulator of neuronal migration in the developing central nervous system. CDK5 phosphorylates a diverse list of substrates, implicating it in the regulation of a range of cellular processes - from adhesion and motility, to synaptic plasticity and drug addiction.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: CDK5 activator 1; CDK5-SV; Cell division protein kinase 5; Cyclin-dependent kinase 5; Cyclin-dependent-like kinase 5; protein kinase CDK5 splicing; Serine/threonine-protein kinase PSSALRE; Tau protein kinase II catalytic subunit; TPKII catalytic subunit

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基因别名: CDK5; CDKN5; LIS7; PSSALRE

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UniProt ID: (Human) Q00535

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Entrez Gene ID: (Human) 1020

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p53 binding protein kinase activity protein serine/threonine kinase activity cyclin-dependent protein serine/threonine kinase activity ErbB-2 class receptor binding protein binding ATP binding cytoskeletal protein binding kinase activity protein kinase binding acetylcholine receptor activator activity ErbB-3 class receptor binding ephrin receptor binding tau-protein kinase activity non-receptor serine/threonine protein kinase

neuron migration synaptic transmission, dopaminergic intracellular protein transport nucleocytoplasmic transport cell cycle cell-matrix adhesion chemical synaptic transmission synapse assembly skeletal muscle tissue development motor neuron axon guidance cell proliferation visual learning response to wounding Schwann cell development synaptic vesicle exocytosis regulation of macroautophagy phosphorylation peptidyl-serine phosphorylation peptidyl-threonine phosphorylation sensory perception of pain cerebellar cortex formation hippocampus development layer formation in cerebral cortex central nervous system neuron development corpus callosum development neuron differentiation regulation of cell migration negative regulation of axon extension cortical actin cytoskeleton organization neuron projection development negative regulation of protein ubiquitination negative regulation of synaptic plasticity positive regulation of protein binding receptor catabolic process serine phosphorylation of STAT3 protein synaptic transmission, glutamatergic protein localization to synapse regulation of apoptotic process receptor clustering positive regulation of neuron apoptotic process negative regulation of cell cycle positive regulation of protein kinase activity negative regulation of proteolysis negative regulation of transcription, DNA-templated positive regulation of calcium ion-dependent exocytosis protein autophosphorylation negative regulation of protein export from nucleus behavioral response to cocaine regulation of synaptic plasticity synaptic vesicle endocytosis rhythmic process axon extension oligodendrocyte differentiation dendrite morphogenesis cell division neuron apoptotic process excitatory postsynaptic potential regulation of dendritic spine morphogenesis calcium ion import regulation of cell cycle arrest positive regulation of protein targeting to membrane negative regulation of neuron death regulation of signal transduction by p53 class mediator regulation of synaptic vesicle recycling positive regulation of actin cytoskeleton reorganization positive regulation of receptor activity