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CDK8 Antibody (PA5-85290) in IHC (P)
CDK8 Polyclonal Antibody detects CDK8 protein at cytoplasm and nucleus in mouse testis by immunohistochemical analysis. Sample: Paraffin-embedded mouse testis. CDK8 Polyclonal Antibody (Product # PA5-85290) diluted at 1:500. Antigen Retrieval: Citrate buffer, pH 6.0, 15 min.
产品信息
PA5-85290
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human CDK8.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
0.1M tris glycine, pH 7, with 10% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2792433
产品详细信息
Keep as concentrated solution.
Predicted reactivity: Mouse (100%), Rat (100%), Zebrafish (100%), Xenopus laevis (100%), Rhesus Monkey (100%).
Positive Control: A549, H1299, HCT116.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
CDK8 phosphorylates the carboxy-terminal domain of the largest subunit of RNA polymerase II. This protein is coexpressed and copurified with Cyclin C. CDK8 is part of a family of proteins designated as cdks are critical regulators of cell cycle progression. The prototype member of this family, p34/Cdc 2, and a related protein Cdk 2, function late in the cycle while Cdk 4 and Cdk 6 are critically involved in G1 to S progression. Because of analogy with yeast Cdk 8, it has been proposed that the human Cdk 8 Cyclin C may interact with RNA polymerase, thus influencing the transcription mechanism(s) that lead to cell division.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CDK8 protein kinase; Cell division protein kinase 8; Cyclin-dependent kinase 8; Mediator complex subunit CDK8; Mediator of RNA polymerase II transcription subunit CDK8; MGC126074; MGC126075; Protein kinase K35
基因别名: CDK8; K35
UniProt ID: (Human) P49336, (Mouse) Q8R3L8
Entrez Gene ID: (Human) 1024, (Mouse) 264064
protein kinase activity
protein serine/threonine kinase activity
cyclin-dependent protein serine/threonine kinase activity
protein binding
ATP binding
RNA polymerase II carboxy-terminal domain kinase activity
nucleotide binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
ubiquitin protein ligase activity
non-receptor serine/threonine protein kinase
transcription initiation from RNA polymerase II promoter
protein phosphorylation
positive regulation of transcription from RNA polymerase II promoter
regulation of cell cycle
transcription, DNA-templated
regulation of transcription, DNA-templated
phosphorylation
protein ubiquitination
negative regulation of triglyceride metabolic process
