Invitrogen

CDKL5 Recombinant Rabbit Monoclonal Antibody (1H57L44)

CDKL5 Antibody in Immunocytochemistry (ICC/IF)

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CDKL5 Antibody (703756) in ICC/IF

For immunofluorescence analysis, SH-SY5Y cells were fixed and permeabilized for detection of endogenous CDKL5 using Anti-CDKL5 Recombinant Rabbit Monoclonal Antibody (Product # 703756, 1:100 dilution) and labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, Alexa Fluor® 488 conjugate (Product # A27034, 1:2000). Panel a) shows representative cells that were stained for detection and localization of CDKL5 protein (green), Panel b) is stained for nuclei (blue) using ProLong™ Diamond Antifade Mountant with DAPI (Pro... View More

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CDKL5 Antibody — Antibody specificity was demonstrated by the detection of differential basal expression of the target across tissue models owing to their inherent genetic constitution. Expression of CDKL5 was observed specifically in Mouse Brain in comparison to Mouse Skeletal muscle tested using Anti-CDKL5 Recombinant Rabbit Monoclonal Antibody (Product # 703756) in western blot. (PMID: 16330482) {RE}

产品信息

703756

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:1,000

免疫细胞化学 (ICC/IF)

1:100

产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

Expression System

Expi293

分类

Recombinant Monoclonal

类型

Antibody

克隆号

1H57L44

抗原

Protein corresponding to human CDKL5 [aa636-aa774]

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.5 mg/mL

纯化类型

Protein A

保存液

PBS, pH 7.4

内含物

0.09% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

AB_2866472

产品详细信息

This antibody is predicted to react with Bovine.

靶标信息

CDKL5 serine/threonine kinase (STK9) is associated with X-linked infantile spasm syndrome (ISSX), also known as X-linked West syndrome and Rett syndrome (RTT). CDKL5 can control nuclear speckle morphology by regulating the phosphorylation state of splicing regulatory proteins, and may be involved indirectly in pre-mRNA processing by controlling splicing factor dynamics. The mutations in CDKL5 are major cause of infantile spasms and early epileptic seizures in female patients, and of a later intractable seizure disorder.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: cyclin dependent kinase 5 transcript; Cyclin-dependent kinase-like 5; RP1-245G19.3; serine/threonine kinase 9; Serine/threonine-protein kinase 9

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基因别名: BC038161; CDKL5; CFAP247; EIEE2; ISSX; STK9

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UniProt ID: (Human) O76039, (Mouse) Q3UTQ8

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Entrez Gene ID: (Human) 6792, (Mouse) 382253, (Rat) 100362725

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功能