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CDKN3 Antibody (PA5-106908) in ICC/IF
Immunocytochemistry analysis of CDKN3 in Hela cells. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25°C. Samples were incubated with CDKN3 polyclonal antibody (Product # PA5-106908) and mouse anti-beta tubulin antibody for 1 hour at 37°C. An AlexaFluor594 conjugated goat anti-rabbit IgG (Red) and an AlexaFluor488 conjugated goat anti-mouse IgG (Green) were used as the secondary antibodies. The nuclear counter stain is DAPI (blue).
产品信息
PA5-106908
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human CDKN3(Accession Q16667), corresponding to amino acid residues L32-G82.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2854572
产品详细信息
Antibody detects endogenous levels of total CDKN3.
靶标信息
The protein encoded by this gene belongs to the dual specificity protein phosphatase family. It was identified as a cyclin-dependent kinase inhibitor, and has been shown to interact with, and dephosphorylate CDK2 kinase, thus prevent the activation of CDK2 kinase. This gene was reported to be deleted, mutated, or overexpressed in several kinds of cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Cdk-associated protein phosphatase; CDK2-associated dual specificity phosphatase; CDK2-associated dual-specificity phosphatase; CDK2-associated dual-specificity phosphatase {ECO:0000250|UniProtKB:Q16667}; cdkn3; cdkn3 {ECO:0000312|EMBL:AAI67026.1, ECO:0000312|RGD:1307781}; cyclin-dependent kinase inhibitor; Cyclin-dependent kinase inhibitor 3; cyclin-dependent kinase inhibitor 3 {ECO:0000250|UniProtKB:Q16667}; cyclin-dependent kinase interacting protein 2; Cyclin-dependent kinase interactor 1; Cyclin-dependent kinase-interacting protein 2; kinase associated phosphatase; Kinase-associated phosphatase; kinase-associated phosphatase {ECO:0000250|UniProtKB:Q16667}
基因别名: 2410006H10Rik; CDI1; CDKN3; CIP2; KAP; KAP1
UniProt ID: (Human) Q16667, (Mouse) Q810P3
Entrez Gene ID: (Human) 1033, (Mouse) 72391, (Rat) 289993
