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CEL Antibody (PA5-115005) in ICC/IF
Immunocytochemistry analysis of CEL in 3T3 cells. Samples were treated with PFA, permeabilized in 0.1% Triton X-100, blocked in 10% serum (45 min at 25°C), and incubated with polyclonal antibody (Product # PA5-115005) at a dilution of 1:200 (1 hr at 37°C). Secondary staining was applied with mouse anti-beta tubulin; AlexaFluor 594 conjugated goat anti-rabbit IgG (Red); AlexaFluor 88 conjugated goat anti-mouse IgG (Green) and DAPI (blue) using a dilution of 1:200 (1 hr at 37°C).
产品信息
PA5-115005
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human CEL(Accession P19835), corresponding to amino acid residues R478-S528.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2899641
产品详细信息
Antibody detects endogenous levels of total CEL.
靶标信息
Caboxyl Ester Lipase (CEL), also known as Bile Salt-Activated Lipase, catalyzes the hydrolysis of a wide range of substrates including cholesteryl esters, phospholipids, lysophospholipids, di- and tri-acylglycerols, and fatty acid esters of hydroxy fatty acids (FAHFAs). Preferentially hydrolyzes FAHFAs with the ester bond further away from the carboxylate. Unsaturated FAHFAs are hydrolyzed more quickly than saturated FAHFAs. It also has an essential role in the complete digestion of dietary lipids and their intestinal absorption, along with the absorption of fat-soluble vitamins. [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: BAL; Bile salt-activated lipase; bile salt-dependent lipase, oncofetal isoform; Bile salt-stimulated lipase; BSSL; bucelipase; carboxyl ester hydrolase; Carboxyl ester lipase; carboxyl ester lipase (bile salt-stimulated lipase); Cholesterol esterase; fetoacinar pancreatic protein; lysophospholipase, pancreatic; Pancreatic lysophospholipase; Sterol esterase
基因别名: 1810036E18Rik; BAL; BSDL; BSSL; CEase; Cel; CELL; FAP; FAPP; Lip1; LIPA; MODY8
UniProt ID: (Mouse) Q64285
Entrez Gene ID: (Human) 1056, (Mouse) 12613
catalytic activity
sterol esterase activity
triglyceride lipase activity
receptor activity
protein binding
heparin binding
hydrolase activity
neurexin family protein binding
acylglycerol lipase activity
carboxylic ester hydrolase activity
lysophospholipase activity
protein complex binding
glycosphingolipid binding
retinyl-palmitate esterase activity
cell adhesion molecule
lipid metabolic process
triglyceride metabolic process
cholesterol catabolic process
neuron cell-cell adhesion
synapse assembly
fatty acid catabolic process
protein esterification
pancreatic juice secretion
intestinal cholesterol absorption
lipid digestion
intestinal lipid catabolic process
modulation of synaptic transmission
lipid catabolic process
retinol metabolic process
ceramide catabolic process
