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Product Details
PA5-69813
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
synthetic peptide corresponding to a region of mouse CELA1 (aa 80-129).
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2689954
Product Specific Information
This target displays homology in the following species: Cow: 100%; Dog: 92%; Horse: 85%; Human: 100%; Mouse: 92%; Pig: 85%; Rabbit: 86%; Rat: 100%
Target Information
Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, pancreatic elastase 1 is not expressed in the pancreas. To date, elastase 1 (ELA1) expression has only been detected in skin keratinocytes. Clinical literature that describes human elastase 1 activity in the pancreas is actually referring to elastase 2A.Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, pancreatic elastase 1 is not expressed in the pancreas. To date, elastase 1 expression has only been detected in skin keratinocytes. Clinical literature that describes human elastase 1 activity in the pancreas is actually referring to elastase 2A.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Chymotrypsin-like elastase family member 1; elastase 1, pancreatic; Elastase-1
Gene Aliases: 1810009A17Rik; 1810062B19Rik; Cela1; Ela-1; Ela1; PC-TsF
UniProt ID: (Mouse) Q91X79
Entrez Gene ID: (Mouse) 109901
negative regulation of transcription from RNA polymerase II promoter
proteolysis
inflammatory response
post-embryonic development
Wnt signaling pathway
exocrine pancreas development
multicellular organism growth
regulation of cell proliferation
regulation of cell differentiation
positive regulation of transcription from RNA polymerase II promoter
digestive system development
pancreas morphogenesis
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