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产品信息
PA5-59939
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein corresponding to Human CENPE
偶联物
形式
Liquid
浓度
0.4 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2639648
产品详细信息
Immunogen sequence: EKIENLTRML VTSSSLTLQQ ELKAKRKRRV TWCLGKINKM KNSNYADQFN IPTNITTKTH KLSINLLREI DESVCSESDV FSNTLDTLSE IEWNPATKLL NQENIESELN SLRADYDN
Highest antigen sequence identity to the following orthologs: Mouse - 56%, Rat - 60%.
靶标信息
14-3-3 sigma (stratifin, SFN, epithelial cell marker protein 1) is a member of a highly conserved family of 14-3-3 proteins that are present in all eukaryotic organisms. There are 7 known mammalian 14-3-3 isoforms epsilon, beta, zeta, gamma, theta, tau and they play important roles in many biological activities by binding to and altering the subcellular localization and/or stability of key molecules in various signaling cascades. 14-3-3 sigma was originally characterized as a human mammary epithelium marker and later rediscovered as an important molecule for cell cycle checkpoint regulation. Recently it has been reported that 14-3-3 sigma may serve as a prognosis marker predicting survival of pancreatic cancer patient treatment. 14-3-3 sigmais the only 14-3-3 isoform induced by the tumor suppressor protein p53, in response to g-irradiation and other DNA-damaging agents. 14-3-3 sigmais a p53-regulated inhibitor of G2/M progression and acts as a tumor suppressor gene that is inactivated by methylation of its 5' CpG islands in epithelial tumor cells. Two isoforms of human 14-3-3 sigma are produced by alternative splicing.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CENP-E; Centromere autoantigen E (312kD); Centromere protein E; centromere protein E, 312kDa; Centromere-associated protein E; kinesin family member 10; Kinesin-7; Kinesin-related protein CENPE; protein phosphatase 1, regulatory subunit 61
基因别名: CENP-E; CENPE; KIF10; MCPH13; PPP1R61
UniProt ID: (Human) Q02224
Entrez Gene ID: (Human) 1062
mitotic cell cycle
retrograde vesicle-mediated transport, Golgi to ER
microtubule-based movement
chromosome segregation
sister chromatid cohesion
mitotic chromosome movement towards spindle pole
mitotic metaphase plate congression
multicellular organism development
antigen processing and presentation of exogenous peptide antigen via MHC class II
regulation of mitotic metaphase/anaphase transition
positive regulation of protein kinase activity
cell division
attachment of mitotic spindle microtubules to kinetochore
kinetochore assembly
