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产品信息
PA5-34441
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Not Applicable
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A 16 amino acid synthetic peptide near the amino terminus of human CENPW
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.02% sodium azide
保存条件
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2551793
产品详细信息
A suggested positive control is Hela cell lysate.
PA5-34441 can be used with blocking peptide PEP-1483.
靶标信息
CENPW was initially identified as a gene that was upregulated in multiple cancers, and whose overexpression in mouse fibroblast cells gave rise to distinct cancer-specific phenotypes. It was later found to be a nuclear protein that associated with CENPT, a component of CENPA nucleosome complex in the centromere, and is required for proper kinetochore function. CENPW also specifically interacts with the nucleolar phosphoprotein nucleophosmin, also known as B23 It has been suggested that nucleophosmin functions in the assembly of the kinetochore by interacting with CENPW during interphase. Overexpression of CENPW in the SKOV-3 human ovarian cancer cell line as well as in the zebrafish embryo led to apoptosis, suggesting that high levels of CENPW induces apoptotic cell death.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Cancer-up-regulated gene 2 protein; cancer-upregulated gene 2; CANP-W; CENP-W; Centromere protein W
基因别名: 2610036L11Rik; C6orf173; CENP-W; CENPW; CUG2
UniProt ID: (Human) Q5EE01, (Mouse) Q3URR0, (Rat) A1L1L1
Entrez Gene ID: (Human) 387103, (Mouse) 66311, (Rat) 689399
