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CGRP Antibody (OSC00190W-100UL) in IHC (P)
IHC-P on paraffin sections of mouse spinal cord. The animal was perfused using Autoperfuser at a pressure of 130 mmHg with 200 mL 4% FA being processed for paraffin embedding. HIER: Tris-EDTA, pH 9 for 20 min using Thermo PT Module. Blocking: 0.2% LFDM in TBST filtered thru 0.2 µm. Detection was done using Novolink HRP polymer from Leica following manufacturers instructions; DAB chromogen: Candela DAB chrom... View More
产品信息
OSC00190W-100UL
产品规格
种属反应
Mouse,
Rat
已发表种属
Not Applicable
宿主/亚型
Rabbit
/ Ig
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide from mouse CGRP conjugated to blue carrier protein was used as the antigen
偶联物
形式
Lyophilized
浓度
Conc. Not Determined
保存液
whole serum
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity of this antibody: CGRP.
靶标信息
This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Alpha-type CGRP; Calcitonin; Calcitonin gene-related peptide 1; Calcitonin gene-related peptide I; calcitonin/calcitonin-related polypeptide, alpha; CGRP-I; MGC126648; RAT calcitonin
基因别名: CA; Cal1; CAL6; Calc; Calc1; Calca; calcitonin; CGRP; CGRP-1; CGRP1; Ct; Ctn; RATCAL6
UniProt ID: (Rat) P01257, (Mouse) P70160
Entrez Gene ID: (Rat) 24241, (Mouse) 12310
endothelial cell proliferation
vasculature development
neurological system process involved in regulation of systemic arterial blood pressure
vasodilation of artery involved in baroreceptor response to increased systemic arterial blood pressure
regulation of heart rate
G-protein coupled receptor internalization
monocyte chemotaxis
protein phosphorylation
cellular calcium ion homeostasis
inflammatory response
leukocyte cell-cell adhesion
adenylate cyclase-activating G-protein coupled receptor signaling pathway
activation of adenylate cyclase activity
positive regulation of cytosolic calcium ion concentration
neuropeptide signaling pathway
neuromuscular junction development
embryo implantation
aging
feeding behavior
regulation of heart contraction
regulation of blood pressure
response to heat
negative regulation of calcium ion transport into cytosol
negative regulation of ossification
positive regulation of cAMP biosynthetic process
receptor internalization
negative regulation of neurological system process
activation of protein kinase activity
positive regulation of interleukin-1 alpha production
positive regulation of interleukin-8 production
vasodilation
endothelial cell migration
positive regulation of macrophage differentiation
negative regulation of osteoclast differentiation
positive regulation of adenylate cyclase activity
negative regulation of blood pressure
positive regulation of ossification
negative regulation of bone resorption
positive regulation of cell adhesion
negative regulation of transcription, DNA-templated
positive regulation of vasodilation
negative regulation of smooth muscle contraction
response to pain
detection of temperature stimulus involved in sensory perception of pain
regulation of cytosolic calcium ion concentration
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
cellular response to tumor necrosis factor
cellular response to nerve growth factor stimulus
sperm capacitation
mitophagy in response to mitochondrial depolarization
