Invitrogen

CGRP Polyclonal Antibody

CGRP Antibody in Immunohistochemistry (IHC)

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CGRP Antibody (PA1-85250) in IHC

BMC biology 2020 - Fig. 5 Peripheral TRPA1 and central TRPV4 contribute to thalidomide-induced mechanical allodynia. a , b Mechanical allodynia at day 7 following intraperitoneal (i.p.) thalidomide (Thal, 50 mg/kg) or Veh and after the administration of intraplantar (i.pl., 20 mul) or intrathecal (i.th., 5 mul) HC-030031 (HC03, 100 mug), HC-067047 (HC06, 100 mug), or Veh. c , d Mechanical allodynia at day 7 following Thal (50... View More

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产品信息

PA1-85250

应用

建议稀释比

已发表文章

免疫组化 (IHC)

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免疫组化（石蜡） (IHC (P))

Assay-dependent

免疫组化（冰冻） (IHC (F))

Assay-dependent

免疫细胞化学 (ICC/IF)

Assay-dependent

酶联免疫吸附实验 (ELISA)

1:500-1:2,500

产品规格

种属反应

Mouse, Rat

已发表种属

Mouse

宿主/亚型

Goat / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic rat Tyr-CGRP (23-37).

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

5 mg/mL

纯化类型

Protein G

保存液

PBS

内含物

0.09% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

AB_2259435

产品详细信息

Goat anti Rat Calcitonin Gene-Related Peptide antibody recognizes Calcitonin gene-related peptide, also known as CGRP, a neuropeptide that acts as a vasodilator and plays a role in in the pathophysiology of migraine (Recober & Russo 2009).

靶标信息

This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Oxidative stress mediates thalidomide-induced pain by targeting peripheral TRPA1 and central TRPV4.

BMC biology

De Logu F,Trevisan G,Marone IM,Coppi E,Padilha Dalenogare D,Titiz M,Marini M,Landini L,Souza Monteiro de Araujo D,Li Puma S,Materazzi S,De Siena G,Geppetti P,Nassini R

PA1-85250 was used in Immunohistochemistry to suggest that targeting of peripheral TRPA1 and central TRPV4 may be required to attenuate pain associated with CIPN elicited by thalidomide and related drugs.

Mon Dec 14 00:00:00 UTC 2020

Oxidative stress mediates thalidomide-induced pain by targeting peripheral TRPA1 and central TRPV4.

BMC biology

De Logu F,Trevisan G,Marone IM,Coppi E,Padilha Dalenogare D,Titiz M,Marini M,Landini L,Souza Monteiro de Araujo D,Li Puma S,Materazzi S,De Siena G,Geppetti P,Nassini R

Mon Dec 14 00:00:00 UTC 2020

生物信息学

蛋白别名: Alpha-type CGRP; Calcitonin; Calcitonin gene-related peptide 1; Calcitonin gene-related peptide I; calcitonin/calcitonin-related polypeptide, alpha; CGRP-I; MGC126648; RAT calcitonin

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基因别名: CA; Cal1; CAL6; Calc; Calc1; Calca; calcitonin; CGRP; CGRP-1; CGRP1; Ct; Ctn; RATCAL6

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UniProt ID: (Rat) P01257, (Mouse) P70160

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Entrez Gene ID: (Rat) 24241, (Mouse) 12310

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功能

receptor binding neuropeptide hormone activity calcitonin receptor binding protein complex binding identical protein binding hormone activity peptide hormone

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